AI Article Synopsis
- The study examined the effects of genistein, hormone replacement therapy, and placebo on RANKL and OPG levels in postmenopausal women over one year.
- Genistein and hormone replacement therapy significantly lowered the sRANKL/OPG ratio compared to placebo, suggesting a positive impact on bone health.
- A correlation was found between changes in the sRANKL/OPG ratio and markers for bone resorption and density, indicating that the sRANKL-OPG system may play a role in bone remodeling benefits from genistein.
Article Abstract
We investigated the serum levels of both receptor activator of nuclear factor kappaB ligand (RANKL) and its decoy receptor osteoprotegerin (OPG) in postmenopausal healthy women after a 1-yr therapy with genistein, (n = 30; 54 mg/d), hormone replacement therapy (n = 30; 1 mg/d 17beta-estradiol combined with norethisterone acetate) and placebo (n = 30). By comparison with placebo, the soluble RANKL (sRANKL)/OPG ratio was lower in the genistein group (-69 +/- 7%; P < 0.01 vs. placebo 81 +/- 24%) and in hormone replacement therapy-treated women (-11 +/- 2%; P < 0.01 vs. placebo). A positive correlation (r = 0.63; P < 0.01) was found between 1-yr percentage change in sRANKL/OPG ratio and 1-yr change in urinary deoxypyridinoline, a bone resorption marker. A negative correlation was observed between 1-yr percentage change in sRANKL/OPG ratio and 1-yr change in femoral neck bone mineral density (r = -0.7; P < 0.01). Our findings suggest that the sRANKL-OPG system may mediate the beneficial effects of genistein on bone remodeling in postmenopausal women.
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| http://dx.doi.org/10.1210/jc.2003-030891 | DOI Listing |
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