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Hydrolysis of N- and S-monomethyl derivatives of 2-thiophenobarbital. | LitMetric

Hydrolysis of N- and S-monomethyl derivatives of 2-thiophenobarbital.

Acta Pol Pharm

Department of Organic Chemistry, Medical College, Jagiellonian University, 9 Medyczna Str., 30-688 Kraków, Poland.

Published: February 2004

Kinetics of hydrolysis of S-methyl-2-thiophenobarbital in aqueous solutions was investigated using the UV spectroscopic method within the pH range 1.5-12.9 at 60 degrees C. Chromatography was used to separate and isolate the products of hydrolysis of this compound and its N-methyl isomer. The products were identified by spectroscopic methods and the course of hydrolysis of both isomers were compared.

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