In experiments on rats we studied the effects of antioxidant and membrane-protecting agent mexidol and neuropeptides delta sleep-inducing peptide and oxytocin administered during resuscitation after 12-min clinical death. Individual and combination treatment with these substances accelerated recovery of the neurological status and partially or completely corrected behavioral disorders associated with changes in the emotional and motivational status. Combined administration of mexidol and oxytocin most significantly promoted postresuscitation recovery of functional activity in the central nervous system.

Download full-text PDF

Source
http://dx.doi.org/10.1023/b:bebm.0000010948.51981.fbDOI Listing

Publication Analysis

Top Keywords

postresuscitation recovery
8
recovery functional
8
functional activity
8
activity central
8
central nervous
8
nervous system
8
combination treatment
8
mexidol neuropeptides
8
neuropeptides delta
8
delta sleep-inducing
8

Similar Publications

Background: The combined therapy with venoarterial extracorporeal membrane oxygenation and Impella (ECPella) has been shown to improve survival in acute cardiogenic shock (CS) in adult patient. Only three paediatric cases have been reported in a multicentre study.

Case Summary: We present our case, the first described to our knowledge in the UK, of a 15-year-old adolescent of Afro-Caribbean descent, weight 75 kg, who received extracorporeal cardiopulmonary resuscitation (E-CPR) and ECPella implantation.

View Article and Find Full Text PDF

Background: The effectiveness of acetated Ringer's solution in pediatric shock has received little attention. This study aimed to assess the clinical outcomes of using compound sodium acetate Ringer's solution (AR) for fluid resuscitation in children with septic shock.

Methods: We retrospectively analyzed the clinical data of children with septic shock admitted to the pediatric intensive care unit of the Affiliated Hospital of Southwest Medical University from December 2019 to January 2023.

View Article and Find Full Text PDF

Objectives: Early initiation of targeted temperature management (TTM) is crucial for post-resuscitation care. Although TTM is initiated prior to transport and continued during interhospital transport (IHT), its feasibility and safety during IHT for cardiac arrest patients have not been thoroughly assessed. This study aims to evaluate the feasibility and safety of interhospital TTM for post-resuscitation patients.

View Article and Find Full Text PDF

Endogenous orexin and hyperacute autonomic responses after resuscitation in a preclinical model of cardiac arrest.

Front Neurosci

September 2024

Departments of Neurology, Anesthesiology-Critical Care Medicine and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Article Synopsis
  • The study investigates how autonomic responses during the recovery from cardiac arrest (CA) are influenced by orexin, specifically examining whether the endogenous orexin promotes rapid cardiovascular sympathetic activity after resuscitation and how this is affected by the drug suvorexant, which blocks orexin receptors.
  • Using a rat model, the researchers monitored heart rate and blood pressure changes following CA, measuring the balance between sympathetic and parasympathetic activities through heart rate variability, while also assessing the levels of plasma orexin-A and neurological outcomes.
  • Findings showed that heart rate significantly increased shortly after resuscitation, correlating with better neurological outcomes, and this response was reduced when the rats were treated with suvore
View Article and Find Full Text PDF
Article Synopsis
  • * A 34-year-old man initially showed no brain abnormalities on scans, but later imaging revealed significant microbleeds specifically in the corpus callosum, pointing to a unique type of brain injury.
  • * The patient received intensive care and targeted temperature management, leading to a positive outcome with significant recovery and no neurological deficits, although the long-term effects of such microbleeds remain unclear.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!