In experiments on rats we studied the effects of antioxidant and membrane-protecting agent mexidol and neuropeptides delta sleep-inducing peptide and oxytocin administered during resuscitation after 12-min clinical death. Individual and combination treatment with these substances accelerated recovery of the neurological status and partially or completely corrected behavioral disorders associated with changes in the emotional and motivational status. Combined administration of mexidol and oxytocin most significantly promoted postresuscitation recovery of functional activity in the central nervous system.
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http://dx.doi.org/10.1023/b:bebm.0000010948.51981.fb | DOI Listing |
Eur Heart J Case Rep
December 2024
PICU, Level 4, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.
Background: The combined therapy with venoarterial extracorporeal membrane oxygenation and Impella (ECPella) has been shown to improve survival in acute cardiogenic shock (CS) in adult patient. Only three paediatric cases have been reported in a multicentre study.
Case Summary: We present our case, the first described to our knowledge in the UK, of a 15-year-old adolescent of Afro-Caribbean descent, weight 75 kg, who received extracorporeal cardiopulmonary resuscitation (E-CPR) and ECPella implantation.
BMC Pediatr
November 2024
Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan Province, China.
Background: The effectiveness of acetated Ringer's solution in pediatric shock has received little attention. This study aimed to assess the clinical outcomes of using compound sodium acetate Ringer's solution (AR) for fluid resuscitation in children with septic shock.
Methods: We retrospectively analyzed the clinical data of children with septic shock admitted to the pediatric intensive care unit of the Affiliated Hospital of Southwest Medical University from December 2019 to January 2023.
Prehosp Emerg Care
November 2024
Department of Emergency Medicine, Seoul National University Hospital and College of Medicine, Seoul, Korea.
Objectives: Early initiation of targeted temperature management (TTM) is crucial for post-resuscitation care. Although TTM is initiated prior to transport and continued during interhospital transport (IHT), its feasibility and safety during IHT for cardiac arrest patients have not been thoroughly assessed. This study aims to evaluate the feasibility and safety of interhospital TTM for post-resuscitation patients.
View Article and Find Full Text PDFFront Neurosci
September 2024
Departments of Neurology, Anesthesiology-Critical Care Medicine and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Medicine (Baltimore)
August 2024
Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA.
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