We studied the effect of plant triterpenoid miliacin on dexamethasone-induced apoptosis in thymocytes and splenocytes. Miliacin produced a protective effect on splenocytes by decreasing the degree of DNA fragmentation due to blockade of the cascade cell death distally to the intramembrane phosphatidylserine translocation.
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http://dx.doi.org/10.1023/b:bebm.0000010945.81238.b6 | DOI Listing |
J Cosmet Dermatol
February 2020
Robertet Group, Grasse, France.
Background: Miliacin, the main triterpenoid from millet, is known to stimulate keratinocyte metabolism and proliferation. Polar lipids are able to form vesicles with active compounds and to improve their bioavailability.
Objectives: We aimed to demonstrate potential benefits of a solution of miliacin encapsulated within polar lipids (MePL) on telogen effluvium prevention and hair condition in women.
Aim: Evaluate the effect of miliacin on the intensity of endotoxinemia and features of cytokine production in experimental salmonella infection.
Materials And Methods: The studies were carried out in 128 male mice (CBAxC57Bl6)F1 divided into 4 groups: I--intact; II--infected; III--infected after administration of miliacin solvent: tween-21; IV--infected after administration of miliacin. Determination of the endotoxin in blood plasma was carried out by using chromogenic LAL-test.
Zh Mikrobiol Epidemiol Immunobiol
March 2014
Aim: Evaluation of influence of triterpenoid miliacin on the development of experimental salmonellosis infection.
Materials And Methods: Studies were carried out in 330 male mice (CBAxC57Bl6)F1. Miliacin was administered 3 times intraperitoneally with the interval of 3 days between administrations at a single dose of 2 mg/kg.
We studied the role of the natural triterpenoid miliacin (3-3-methoxy-Al8-oleanene) in the regulation of oxidative stress in the liver of (CBAxC57B1(6))F1 mice exposed to methotrexate. Miliacin attenuated methotrexate-induced lipid peroxidation as determined by an attenuation of thiobarbituric acid-reacting products in the liver. Furthermore, miliacin normalized the expression of genes encoding the 2e1 isoform of cytochrome P-450 and glutathione reductase that were dramatically dysregulated by methotrexate.
View Article and Find Full Text PDFRapid Commun Mass Spectrom
October 2011
Institut des Sciences de la Terre d'Orléans-ISTO, Université d'Orléans-Université François Rabelais de Tours, UMR 6113 du CNRS/INSU, 1A rue de la Férollerie, 45072 Orléans, France.
Compound-specific δD analyses of land plant-derived biomarkers preserved in lake sediments are gaining increasing interest in paleoclimatic studies because of their potential to record essential information on the climatic conditions that prevailed at the time of their synthesis. The accuracy of inferences about climate from these analyses could be better constrained with more study of the variability in the δD values of possible inputs at catchment scales. We measured the δD values of miliacin (olean-18-en-3β-ol methyl ether) extracted from the seeds of millet plants collected in 21 stands spatially distributed in a field with visually heterogeneous soil organic matter contents.
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