Two eudesmanolides, eight lactucin-like guaianolides and five phenolic compounds were isolated for the first time from roots of Cichorium pumilum, along with two previously reported eudesmane-type sesquiterpene lactones. Rearrangements of some lactucin-like guaianolides during isolation procedures were also discussed.
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http://dx.doi.org/10.1515/znc-2003-11-1206 | DOI Listing |
Fitoterapia
June 2008
Department of Phytochemistry, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
From aerial parts of Lactuca sibirica, two new and one known furofuran lignans were isolated, together with four known lactucin-like guaianolides. On the basis of spectral data, the new lignans were characterized as acylated glucopyranosides of 4alpha, 8alpha-dihydroxypinoresinol.
View Article and Find Full Text PDFJ Ethnopharmacol
September 2006
Department of New Drugs Research, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Str., 31-343 Krakow, Poland.
Lactucin (1) and its derivatives lactucopicrin (2) and 11beta,13-dihydrolactucin (3), which are characteristic bitter sesquiterpene lactones of Lactuca virosa and Cichorium intybus, were evaluated for analgesic and sedative properties in mice. The compounds showed analgesic effects at doses of 15 and 30 mg/kg in the hot plate test similar to that of ibuprofen, used as a standard drug, at a dose of 30 mg/kg. The analgesic activities of the compounds at a dose of 30 mg/kg in the tail-flick test were comparable to that of ibuprofen given at a dose of 60 mg/kg.
View Article and Find Full Text PDFZ Naturforsch C J Biosci
March 2004
Department of Phytochemistry, Institute of Pharmacology, Polish Academy of Sciences, Pl-31-343 Krakow, Poland.
Two eudesmanolides, eight lactucin-like guaianolides and five phenolic compounds were isolated for the first time from roots of Cichorium pumilum, along with two previously reported eudesmane-type sesquiterpene lactones. Rearrangements of some lactucin-like guaianolides during isolation procedures were also discussed.
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