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Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
BrainCheck, Inc, Austin, TX, USA.
Background: Cognitive care planning-the process of regularly and systematically assessing patient needs and documenting recommendations to address them-improves health and quality of life among patients with cognitive impairments, like Alzheimer's disease and related dementias (ADRD). A cognitive care plan may promote physical exercise, social engagement, healthier eating, medication recommendations, and overall improvement in care management (e.g.
View Article and Find Full Text PDFArtificial Intelligence-Powered Training Database for Clinical Thinking: App Development Study.
JMIR Form Res
January 2025
Centre for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Background: With the development of artificial intelligence (AI), medicine has entered the era of intelligent medicine, and various aspects, such as medical education and talent cultivation, are also being redefined. The cultivation of clinical thinking abilities poses a formidable challenge even for seasoned clinical educators, as offline training modalities often fall short in bridging the divide between current practice and the desired ideal. Consequently, there arises an imperative need for the expeditious development of a web-based database, tailored to empower physicians in their quest to learn and hone their clinical reasoning skills.
View Article and Find Full Text PDFGeneral practice chlamydia testing: qualitative study of staff approaches using behavioural change theory.
Br J Gen Pract
December 2024
UCL, Research Department of Primary Care and Population Health, London, United Kingdom
Background: Chlamydia is the most diagnosed bacterial sexually transmitted infection in England, but opportunistic testing remains low in general practice despite high prevalence among young people. Attempts to increase testing have been met with little success; therefore, there is a need to explore why rates remain low and how this may be improved.
Aim: To explore general practice staff perceptions of opportunistic chlamydia testing, including barriers, facilitators, interventions, and policies, using the Behaviour Change Wheel (BCW).
Reframing prolonged negative mental health effects of COVID-19: cognitive restructuring promotes posttraumatic growth.
Psychol Health
November 2024
Department of Behavioural Sciences, Medical School, University of Pécs, Pécs, Hungary.
Objective: The study aimed to investigate the level of peritraumatic distress in relation to possible traumatic outcomes in university personnel and students across three pandemic waves.
Methods: Three cross-sectional surveys were conducted to investigate university students and staff ( = 1426). An online survey including the COVID-19 Peritraumatic Distress Index (CPDI), Ways of Coping, Impact of Events Scale (IES), and Posttraumatic Growth Inventory (PTGI) were administered across three waves.
Characterization of intermediate states in the fibrillogenesis of odorant-binding proteins.
Int J Biol Macromol
December 2024
Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology of the Russian Academy of Sciences, 4 Tikhoretsky ave., 194064 St. Petersburg, Russia. Electronic address:
The transition of β-barrel proteins from a soluble to an amyloid form is biologically significant in some cases but may lead to functional activity loss. In particular, odorant-binding proteins' (OBPs) fibrils are unable to bind odorant molecules potentially contributing to olfactory dysfunction. As shown previously, OBPs' fibrillogenesis is initiated by uncoupling of protein C-terminal fragment from the β-barrel and exposing amyloidogenic sites.
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