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Investigation of the effects of silymarin and vitamin C on kidney damage and aquaporin-2 downregulation in lithium-induced nephrogenic diabetes insipidus in rats.
Drug Chem Toxicol
January 2025
Department of Pathology, Faculty of Veterinary Medicine, Bingöl University, Bingöl, Turkey.
Although lithium (LIT) therapy is key in managing bipolar disorder long-term, prolonged use significantly contributes to acquired Nephrogenic Diabetes Insipidus (NDI). This study examined whether combining Silymarin (SIL) with Vitamin C (Vit C) enhances protection against lithium-induced nephrotoxicity in rats, comparing their individual antioxidant effects as well. Rats subjected to Li exposure were provided with a standard commercial diet supplemented with 80 mmol LiCl per kilogram for 28 days.
View Article and Find Full Text PDFLithium-induced apoptotic cell death is not accompanied by a noticeable inflammatory response in the kidney.
Front Physiol
August 2024
Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Lithium (Li) therapy is a valuable tool in psychiatric practice that remains underutilized due to safety concerns. Excessive plasma Li levels are nephrotoxic and can trigger a local immune response. Our understanding of the immunomodulatory effects of Li in the kidney is fragmentary.
View Article and Find Full Text PDFDuloxetine-Induced Antidiuresis in Rats with Lithium-Induced Nephrogenic Diabetes Insipidus.
Life (Basel)
August 2024
Biomedical Research Institute, Hanyang University College of Medicine, 222-1 Wansimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea.
Antidepressants, including duloxetine, are a significant cause of drug-induced hyponatremia, which can disrupt the continuation of medication. Tolvaptan is beneficial for correcting hyponatremia caused by the syndrome of inappropriate antidiuresis, but its impact on duloxetine-induced hyponatremia remains unknown. We used male Sprague-Dawley rats to examine the impact of duloxetine treatment on lithium-induced nephrogenic diabetes insipidus (Li-NDI) and to evaluate whether the results were reversed by co-treatment with tolvaptan.
View Article and Find Full Text PDFSuccessful Treatment of Lithium-Induced Nephrogenic Diabetes Insipidus with Celecoxib: A Promising Therapeutic Option.
Am J Case Rep
April 2024
Department of Primary Care and Emergency Medicine, Kyoto University, Kyoto, Japan.
Article Synopsis
- Nephrogenic diabetic insipidus (NDI), especially when linked to lithium ingestion, is challenging to manage clinically, with traditional treatments often yielding minimal improvement.
- *Celecoxib, a selective COX-2 inhibitor, was successfully used to treat a 46-year-old woman with lithium-induced NDI, resulting in significant improvement in her symptoms without adverse effects.
- *This case suggests celecoxib could be a promising alternative treatment for managing lithium-induced NDI, warranting further investigation in clinical settings.
Lithium-induced Nephrogenic Diabetes Insipidus with Efficacy of Desmopressin in Combination with Thiazide Diuretics and Non-steroidal Anti-inflammatory Drugs: A Case Report with a Review of the Literature.
Intern Med
May 2024
Department of Endocrinology and Diabetes, NTT Medical Center Tokyo, Japan.
Article Synopsis
- * Treatment usually includes thiazide diuretics and NSAIDs, with mixed results for desmopressin.
- * In a case study of a 71-year-old woman, thiazide diuretics and NSAIDs cut urine output by 40%, while desmopressin further reduced it by 70%, indicating it may be a useful treatment.
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