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Study protocol: the 'Endoscope CRC' cohort, a prospective biobank study on the development and evaluation of diagnostic and prognostic biomarker profiles for colorectal cancer and premalignant lesions.
BMJ Open
November 2024
Division of Gastroenterology-Hepatology, Department of Internal Medicine, Maastricht Universitair Medisch Centrum+, Maastricht, The Netherlands.
Article Synopsis
- Early detection of colorectal cancer (CRC) can reduce mortality, but existing screening methods like the faecal immunochemical test (FIT) often yield false results, highlighting the need for more accurate tools.
- Research is being conducted on volatile organic compounds (VOCs) found in breath and faeces as potential biomarkers for diagnosing and tracking colorectal neoplasia.
- The study will involve sampling from individuals in the Dutch CRC screening program and utilizes advanced techniques like gas-chromatography-mass spectrometry (GC-MS) along with machine learning for data analysis.
Modeling Radiologists' Assessments to Explore Pairing Strategies for Optimized Double Reading of Screening Mammograms.
Med Decis Making
October 2024
Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Purpose: To develop a model that simulates radiologist assessments and use it to explore whether pairing readers based on their individual performance characteristics could optimize screening performance.
Methods: Logistic regression models were designed and used to model individual radiologist assessments. For model evaluation, model-predicted individual performance metrics and paired disagreement rates were compared against the observed data using Pearson correlation coefficients.
Effect of resistance training and chicken meat on muscle strength and mass and the gut microbiome of older women: A randomized controlled trial.
Physiol Rep
June 2024
Faculty of Sport Sciences, Waseda University, Saitama, Japan.
This study investigated the effects of white meat, such as chicken, intake combined with resistance training on muscle mass and strength in the elderly women, and whether the underlying mechanism involves changes in the gut microbiota. Ninety-three volunteers (age 59-79 years) were randomly allocated to sedentary control with placebo (Sed + PL) or chicken meat (Sed + HP) and resistance training with placebo (RT + PL) or chicken meat (RT + HP). Resistance training sessions were performed 3 d/week for 12 weeks using leg extensions and curls.
View Article and Find Full Text PDFThis commentary responds to Moti Gorin's article "What Is the Aim of Pediatric 'Gender-Affirming' Care?" We argue that Gorin's case against pediatric gender-affirming care rests upon numerous false conceptual binaries: female/male, public/private, objective/subjective, and medically necessary/elective. Drawing on feminist bioethics, we show how such dichotomous thinking is both inaccurate and marginalizing of gender minorities.
View Article and Find Full Text PDFHepatic insulin resistance and muscle insulin resistance are characterized by distinct postprandial plasma metabolite profiles: a cross-sectional study.
Cardiovasc Diabetol
March 2024
Division of Human Nutrition and Health, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
Background: Tissue-specific insulin resistance (IR) predominantly in muscle (muscle IR) or liver (liver IR) has previously been linked to distinct fasting metabolite profiles, but postprandial metabolite profiles have not been investigated in tissue-specific IR yet. Given the importance of postprandial metabolic impairments in the pathophysiology of cardiometabolic diseases, we compared postprandial plasma metabolite profiles in response to a high-fat mixed meal between individuals with predominant muscle IR or liver IR.
Methods: This cross-sectional study included data from 214 women and men with BMI 25-40 kg/m, aged 40-75 years, and with predominant muscle IR or liver IR.
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