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Evaluating the effectiveness of advanced platelet-rich fibrin, photobiomodulation, pentoxifylline, and Alveogyl in the treatment of alveolar osteitis: a randomized controlled clinical trial.
BMC Oral Health
December 2024
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Akdeniz University, Antalya, 07058, Turkey.
Background: Alveolar osteitis is a type of small-scale osteomyelitis of the alveolar bone that occurs after tooth extraction, the etiology of which remains unknown, and alternative methods are being investigated for its treatment. The aim of this study was to compare the effectiveness of advanced platelet-rich fibrin (A-PRF), photobiomodulation (PBM), and Alveogyl (butamben, idoform, eugenol), which have shown success in the treatment of alveolar osteitis, with that of pentoxifylline (PTX) to determine whether PTX could be an alternative treatment for alveolar osteitis.
Methods: This study included 80 healthy volunteers diagnosed with alveolar osteitis in the extraction sockets of their mandibular first, second, and third molars.
Integrating Radioprotective Agents into Post-Mastectomy Radiotherapy: Optimization of Reconstructive Outcomes in Breast Cancer.
J Surg Res (Houst)
October 2024
Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California, USA.
Surgical intervention utilizing various approaches is a cornerstone in the management of breast cancer. The surgical approaches include lumpectomy, mastectomy, axillary lymph node dissection, and primary or delayed reconstruction. Post-mastectomy radiotherapy is frequently recommended in cases of advanced tumors and extensive lymph node involvement.
View Article and Find Full Text PDFGlial-modulating agents for the treatment of pain: a systematic review.
Pain
October 2024
Bracken Health Sciences Library, Queen's University, Kingston, ON, Canada.
Article Synopsis
- Preclinical studies highlight the importance of glial cells in pain mechanisms, leading to a systematic review of human trials on glia-modulating drugs for pain treatment.
- The review included 26 trials with a total of 2,132 participants, focusing on the effects of drugs like minocycline and pentoxifylline, but found significant variability among studies and no conclusive evidence of effectiveness.
- Future research is encouraged to identify optimal glial-targeted drugs, the ideal timing and duration for their use, and improved designs for clinical trials to better assess their potential in pain management.
Improvement of Docetaxel Efficacy through Simultaneous Blockade of Transcription Factors NF-κB and STAT-3 Using Pentoxifylline and Stattic in Prostate Cancer Cells.
Curr Issues Mol Biol
September 2024
Immunology Division, Western Biomedical Research Center, Mexican Institute of Social Security, Guadalajara 44340, Mexico.
Prostate cancer (PCa) is a common and deadly disease in men. It is often diagnosed at advanced stages, at which point patients are treated mainly with docetaxel (DTX), which is effective but limited by resistance and side effects. Overactivation of the transcription factors NF-κB and STAT-3 plays a critical role in the development, progression, and chemoresistance of PCa.
View Article and Find Full Text PDFManaging Mandibular Osteoradionecrosis.
Otolaryngol Head Neck Surg
September 2024
Division of Facial Plastic and Microvascular Surgery, Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Objective: Mandibular osteoradionecrosis (MORN) is a morbid complication of head and neck radiation therapy. Recent advances in surgical and medical therapies underscore the need for a shift in traditional treatment paradigms and a disease grading system that can guide appropriate management.
Data Sources: Pubmed/MEDLINE.
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