Three experiments were conducted to control for the effects of housing conditions during play deprivation on subsequent play rebound in periadolescent rats. To address play deprivation without the confound of social isolation, in Experiment 1, pairs of subjects were housed either in cages divided by wire mesh that allowed for olfactory, visual, auditory, and tactile interactions with a same-sex age-mate but prevented rough and tumble play or in standard cages. Running wheels were provided to similarly housed subjects in Experiment 2 to control for the ability to engage in physical activity. In Experiment 3, standard and brooder cages were used to control for the effects of housing area. Play-deprived subjects in all conditions showed a greatly increased number of play responses immediately following deprivation. The results from these experiments more clearly indicate that the absence of play is the crucial feature that brings about play rebound following deprivation.
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Int J Biol Macromol
January 2025
Department of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. Electronic address:
Mitochondrial dysfunction and ferroptosis play crucial roles in myocardial ischemia/reperfusion (I/R) following heart transplantation. Microsomal glutathione s transferase 1 (MGST1) is widely distributed in mitochondria and has a protective effect against ferroptosis, and its involvement in myocardial I/R injury has not yet been elucidated. In this study, donor hearts from C57BL/6 male mice were subjected to 12 h of ex-vivo cold ischemia treatment and transplanted into the abdomen of recipient mice for 24 h of reperfusion.
View Article and Find Full Text PDFAntioxid Redox Signal
January 2025
Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration (FDA), Silver Spring, Maryland, USA.
The mitochondria play a key role in maintaining oxygen homeostasis under normal oxygen tension (normoxia) and during oxygen deprivation (hypoxia). This is a critical balancing act between the oxygen content of the blood, the tissue oxygen sensing mechanisms, and the mitochondria, which ultimately consume most oxygen for energy production. We describe the well-defined role of the mitochondria in oxygen metabolism with a special focus on the impact on blood physiology and pathophysiology.
View Article and Find Full Text PDFMed Humanit
January 2025
School of European Languages and Cultures, UCL, London, UK
Separated by a gap of 27 years, Anna Reynold's (1992) and Gary Owen's (2015) offer, on the surface, dramaturgically similar critiques of the impact of poverty on motherhood. Both plays are critically acclaimed monologues for women, which describe the death of a baby following inadequate interventions from health and/or social care services. This article examines the different theatrical contexts for these plays and offers a situated reading of the representation of maternal crisis in circumstances of social deprivation.
View Article and Find Full Text PDFBr J Sociol
January 2025
Labour and Public Economics Unit, Paris School of Economics, Paris, France.
This paper analyses the enduring impact of neighbourhood deprivation on youth development, exploring multigenerational aspects often overlooked in existing research. I investigate how neighbourhood environments experienced across two generations impact youth outcomes, focussing on cognitive skills and socio-emotional behaviour. Using data from the 1958 National Child Development Study in the UK, this study employs a Regression with Residuals (RWR) design to comprehensively assess any long-lasting effects.
View Article and Find Full Text PDFTissue Cell
January 2025
Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia. Electronic address:
The extracellular matrix (ECM) and its primary chemical components, including collagen, play a pivotal role in carcinogenesis and tumor progression. The ECM actively regulates cell proliferation, migration, and, importantly, resistance to various adverse factors. It is widely recognized as a key factor in modifying the resistance of tumor cells to various treatment modalities and cytotoxic compounds.
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