Facile O-arylation of phenols and carboxylic acids.

Org Lett

Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.

Published: January 2004

[reaction: see text] A facile, transition-metal-free O-arylation procedure for phenols and aromatic carboxylic acids has been developed that affords good to excellent yields of arylated products under very mild reaction conditions. A methoxy-substituted aryl triflate affords O-arylated products in high yields with excellent regioselectivity. This chemistry tolerates a variety of functional groups.

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Source
http://dx.doi.org/10.1021/ol0361406DOI Listing

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