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Inhibition of Melanin Synthesis and Inflammation by Exosomes Derived from DB-14 Isolated from Flower.
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Department of Pharmaceutical Engineering & Biotechnology, Sunmoon University, Chungnam 31460, Republic of Korea.
is a lactic acid bacteria found in fermented products. In our previous study, was isolated from flowers, and its acid tolerance and antibacterial properties were thoroughly investigated. This study focuses on the inhibition of melanin synthesis and inflammation of exosomes derived from .
View Article and Find Full Text PDFLow Prostaglandin E but High Prostaglandin D, a Paradoxical Dissociation in Arachidonic Acid Metabolism in Aspirin-Exacerbated Airway Disease: Role of Airway Epithelium.
J Clin Med
December 2024
Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, 08907 Barcelona, Spain.
In patients with aspirin-exacerbated respiratory disease (AERD), there is disparate regulation of prostaglandin E2 (PGE) and prostaglandin D (PGD). Both prostanoids are synthesised by cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2). However, while the basal synthesis of PGE tends to decrease, that of PGD increases in patients with AERD.
View Article and Find Full Text PDFProbiotic Characteristics and the Anti-Inflammatory Effects of Z22 Isolated from Naturally Fermented Vegetables.
Microorganisms
October 2024
College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Currently, there is increasing interest in the commercial utilization of probiotics isolated from traditional fermented food products. Therefore, this study aimed to investigate the probiotic potential of () Z22 isolated from naturally fermented mustard. The results suggest that Z22 exhibits good adhesion ability, antibacterial activity, safety, and tolerance to acidic conditions and bile salts.
View Article and Find Full Text PDFPotential role of the antimicrobial peptide Tachyplesin III in regulating nontypeable Haemophilus influenzae-induced inflammation in airway epithelial cells.
Arch Microbiol
November 2024
Department of Microbiology and Parasitology, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand.
Article Synopsis
- Nontypeable Haemophilus influenzae (NTHi) is a major contributor to inflammation in chronic obstructive pulmonary disease (COPD), necessitating new treatments due to limitations of current drugs.
- A study investigated Tachyplesin III, an antimicrobial peptide from horseshoe crabs, and found it significantly reduced key inflammatory markers (like IL-1β and TNF-α) in human lung cells exposed to NTHi without being toxic.
- The research also showed that Tachyplesin III inhibits the NF-κB/NLRP3 signaling pathway, suggesting it could be a valuable new option for addressing NTHi-related airway inflammation in COPD patients.
Systemic chemokine-modulatory regimen combined with neoadjuvant chemotherapy in patients with triple-negative breast cancer.
J Immunother Cancer
November 2024
Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA
Background: Higher cytotoxic T lymphocyte (CTL) numbers in the tumor microenvironment (TME) predict pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) and positive long-term outcomes in triple-negative breast cancer (TNBC). pCR to NAC is achieved only in 30-40% of patients. The combination of NAC with pembrolizumab increases the pCR rate but at the cost of immune-related adverse events (irAEs).
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