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Naringenin, a Food Bioactive Compound, Reduces Oncostatin M Through Blockade of PI3K/Akt/NF-κB Signal Pathway in Neutrophil-like Differentiated HL-60 Cells.
Foods
January 2025
Center for Converging Humanities, Kyung Hee University, Seoul 02447, Republic of Korea.
Oncostatin M (OSM) plays a crucial role in diverse inflammatory reactions. Although the food bioactive compound naringenin (NAR) exerts various useful effects, including antitussive, anti-inflammatory, hepatoprotective, renoprotective, antiarthritic, antitumor, antioxidant, neuroprotective, antidepressant, antinociceptive, antiatherosclerotic, and antidiabetic effects, the modulatory mechanism of NAR on OSM expression in neutrophils has not been specifically reported. In the current work, we studied whether NAR modulates OSM release in neutrophil-like differentiated (d)HL-60 cells.
View Article and Find Full Text PDFAcupuncture therapy in autoimmune diseases: A narrative review.
Autoimmun Rev
November 2024
Reichman University, Herzelia, Israel; Zabludowicz Center for Autoimmune Diseases (Founder), Sheba Medical Center, Tel-Hashomer 5265601, Israel. Electronic address:
We provide a narrative review of experimental and clinical evidence for the effect of acupuncture in autoimmune diseases, based on randomized controlled studies, systematic review and meta-analyses, published between the years 2000-2023. Acupuncture in experimental models of rheumatoid arthritis (RA), multiple sclerosis, psoriasis, ulcerative colitis (UC) downregulated inflammatory cytokine expression, increased IL-10 expression, improved Treg cell differentiation, and also modulated macrophage polarization in RA and UC models. The anti-inflammatory effect of acupuncture in autoimmune disorders has been demonstrated to involve vagal-adrenal and cholinergic anti-inflammatory pathways.
View Article and Find Full Text PDFEnhancing orofacial pain relief: α-phellandrene complexed with hydroxypropyl-β-cyclodextrin mitigates orofacial nociception in rodents.
Naunyn Schmiedebergs Arch Pharmacol
November 2024
Department of Physiology, Federal University of Sergipe (UFS), São Cristóvão, SE, Brazil.
Orofacial pain affects 10-15% of adults and can severely impact quality of life. Despite ongoing treatment challenges, monoterpene alpha-phellandrene (PHE) shows potential therapeutic benefits. This study aimed to develop and evaluate an inclusion complex of PHE with hydroxypropyl-beta-cyclodextrin (PHE-HPβCD) for treating orofacial pain.
View Article and Find Full Text PDFPAR on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451.
Biomaterials
March 2025
New York University Dentistry Translational Research Center, New York University Dentistry, New York, NY, 10010, USA; Pain Research Center, New York University, New York, NY, 10010, USA; Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY, 10016, USA. Electronic address:
Article Synopsis
- Oral cancer causes significant pain linked to the activation of protease-activated receptor 2 (PAR) in cancer cells and neurons, contributing to nociception (pain sensation).
- Researchers found that inhibiting PAR using nanoparticles to deliver the drug AZ3451 is more effective in reversing pain compared to the drug alone, especially in mouse models of oral cancer pain.
- The study also shows that both the overexpression of the F2RL1 gene in cancer cells and neurons plays a role in pain, and targeting PAR could improve pain management and oral function for patients.
Antinociceptive, anti-inflammatory, and antioxidant effects of a flavonoid-rich phytocomplex from the leaves of (jacq.) Sargent (Cannabaceae).
Nat Prod Res
September 2024
Laboratório de Desenvolvimento Farmacotécnico (LADEF), Universidade Federal de São João del-Rei (UFSJ), Campus Centro-Oeste Dona Lindu (CCO), R. Sebastião Gonçalves Coelho, Divinópolis, Brazil.
We demonstrated the antinociceptive and anti-inflammatory effects of the ethyl acetate leaf extract of (Jacq.) Sargent (EAECi) in mice. The antioxidant activity of EAECi and its phytoconstituents was also investigated.
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