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And after surgery, what's new for the rectal cancer survivor?
Cir Esp (Engl Ed)
January 2025
Unidad de Cirugía Colorrectal, Servicio de Cirugía General y Digestiva, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Low anterior resection syndrome is a common but underestimated complication after rectal cancer surgery that significantly impacts the quality of life of the surviving patient. It is characterized by symptoms such as fecal incontinence and voiding dysfunction and affects up to 90% of patients undergoing low anterior rectal resection. The etiology of the syndrome is multifactorial with no clear determining factor.
View Article and Find Full Text PDFA 47-year-old woman, a diagnosed case of syndrome of inappropriate secretion of antidiuretic hormone, underwent 18F-FDG PET/CT to detect occult malignancy for suspected paraneoplastic etiology. Abnormal FDG uptake was noted in the right lower chest region, which was correlated on corresponding CT images to be colonic activity interposed between the liver and elevated diaphragm, also known as Chilaiditi sign. Even though rare, Chilaiditi sign should be considered as a differential diagnosis of hypermetabolic activity in the right lower chest region on 18F-FDG PET/CT scan that is done to look for occult tumor as shown in this case.
View Article and Find Full Text PDFContribution of PKS+ to colon carcinogenesis through the inhibition of exosomal miR-885-5p.
Heliyon
September 2024
Department of Gastrointestinal Surgery, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, China.
Objectives: About 90 % of all colorectal cancer (CRC) fatalities are caused by the metastatic spread of primary tumors, which is closely correlated with patient survival and spreads by circulating tumor cells (CTCs). The epithelial-mesenchymal transition (EMT) that characterizes CTCs is associated with a poor prognosis. Organotropic metastasis is dictated by the transmission of miRNAs by cancer-derived exosomes.
View Article and Find Full Text PDFGSH-responsive polymeric micelles-based augmented photoimmunotherapy synergized with PD-1 blockade for eliciting robust antitumor immunity against colon tumor.
J Nanobiotechnology
September 2024
State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, China.
Article Synopsis
- Phototherapy, which includes photothermal therapy (PTT) and photodynamic therapy (PDT), faces challenges in effectiveness due to tumor hypoxia and the presence of immunosuppressive factors like IDO and PD-L1.
- Researchers developed multifunctional polymeric micelles called RIMNA to deliver a combination of treatments: the photosensitizer ICG, an oxygenator MnO, an IDO inhibitor NLG919, and an immune stimulant MPLA.
- RIMNA showed strong stability and biocompatibility, and effectively improved phototherapy outcomes by enhancing immune activation and reducing tumor growth, indicating a promising strategy for improving cancer treatment.
Testing in functional constipation-What's new and what works.
Aliment Pharmacol Ther
July 2024
Section of Pediatric Gastroenterology, Hepatology and Nutrition, Yale New Haven Children's Hospital, Yale University School of Medicine, New Haven, Connecticut, USA.
Background: Constipation is among the most common symptoms prompting a consultation with a paediatric gastroenterologist. While most patients will respond to lifestyle and dietary changes and conventional therapy, some may require diagnostic studies.
Aim: To review the diagnostics studies used to evaluate children with functional constipation.
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