AI Article Synopsis
- Synapse-specific facilitation relies on local protein synthesis at activated synapses, which requires the drug rapamycin.
- This local protein synthesis serves two key functions: it marks the activated synapse for specificity and stabilizes the growth associated with long-term facilitation.
- A neuron-specific version of a protein called CPEB helps regulate this local protein synthesis in response to neuronal activity, being crucial for the lasting effects of long-term facilitation rather than starting the process.
Article Abstract
Synapse-specific facilitation requires rapamycin-dependent local protein synthesis at the activated synapse. In Aplysia, rapamycin-dependent local protein synthesis serves two functions: (1) it provides a component of the mark at the activated synapse and thereby confers synapse specificity and (2) it stabilizes the synaptic growth associated with long-term facilitation. Here we report that a neuron-specific isoform of cytoplasmic polyadenylation element binding protein (CPEB) regulates this synaptic protein synthesis in an activity-dependent manner. Aplysia CPEB protein is upregulated locally at activated synapses, and it is needed not for the initiation but for the stable maintenance of long-term facilitation. We suggest that Aplysia CPEB is one of the stabilizing components of the synaptic mark.
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| http://dx.doi.org/10.1016/s0092-8674(03)01021-3 | DOI Listing |
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