Laparoscopic assessment of the sentinel node (SN) in early stage cervical cancer is both feasible and safe. The technique is described. The data concerning the 70 first assessed patients are reported. Failure in identification of the SN occurred in 14 of the 139 attempted dissections. One only SN was detected in 121 dissections and two SN in four dissections. A systematic pelvic lymphadenectomy was carried out after removal of the SN. A metastatic involvement of the SN was put in evidence in 19 of the 129 retrieved SN. The other regional lymph nodes were. The data concerning the 70 first assessed patients are reported. Failure in identification of the SN occurred in 14 of the 139 attempted dissections. One only SN was detected in 121 dissections and two SN in four dissections. A systematic pelvic lymphadenectomy was carried out after removal of the SN. A metastatic involvement of the SN was put in evidence in 19 of the 129 retrieved SN. The other regional lymph nodes were involved in 13 cases and not involved in six cases. In the 110 cases where the SN was not involved all the other regional nodes were free from metastasis. At the condition larger series confirm the preliminary results the laparoscopic retrieval of the SN could change the strategy to be used in the management of early stage cervical cancer: no systematic lymphadenectomy-radiotherapy for the SN+ patients--vaginal radical hysterectomy for the SN- patients. Another condition should be the SN is submitted to superstaging using immunochemical staining and/or molecular biology.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s1040-8428(03)00129-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clinical value of multi-slice spiral CT in evaluating preoperative TNN staging and postoperative recurrence and metastasis of colon carcinoma.
SLAS Technol
January 2025
Department of Radiology, Huzhou First People's Hospital, Huzhou 313000, Zhejiang Province, China. Electronic address:
To evaluate the clinical value of multi-slice spiral CT in preoperative TNN staging and postoperative recurrence and metastasis of colon carcinoma, and to provide evidence for the reliability of CT in the diagnosis of colon carcinoma METHODS: 89 patients with colon carcinoma diagnosed pathologically in our hospital from July 2020 to April 2023 were selected retrospectively. The preoperative TNN staging and postoperative recurrence and metastasis were monitored by 64 row 128 layer spiral CT. The diagnostic coincidence rate, TNM staging coincidence rate and postoperative recurrent TNM staging accuracy were evaluated according to the pathological diagnosis RESULTS: The diagnostic coincidence rate of multi-slice spiral CT was 97.
View Article and Find Full Text PDFAntigen affinity and site of immunization dictate B cell recall responses.
Cell Rep
January 2025
Department of Microbiology, Tumor and Cell Biology, Division of Virology and Immunology, Karolinska Institutet, 171 65 Solna, Sweden. Electronic address:
Protective antibodies against HIV-1 require unusually high levels of somatic mutations introduced in germinal centers (GCs). To achieve this, a sequential vaccination approach was proposed. Using HIV-1 antibody knockin mice with fate-mapping genes, we examined if antigen affinity affects the outcome of B cell recall responses.
View Article and Find Full Text PDFSingle-Injection Composite Tracer Achieves Intraoperative Dual-Tracing and Precise Localization of Sentinel Lymph Nodes.
ACS Appl Mater Interfaces
January 2025
Sixth People's Hospital, School of Medicine & School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P. R. China.
The use of dual-tracer contrast agents in clinical applications, such as sentinel lymph node (SLN) identification, offers significant advantages including enhanced accuracy, sensitivity, as well as comprehensive and multimodal visualization. In the current clinical practice, SLNs are typically marked prior to surgical resection by multiple and sequential injections of two tracers, the radioactive tracer and methylene blue (MB) dye. This imposes physical and psychological burden on patients and medical staff.
View Article and Find Full Text PDFDysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma.
World J Gastrointest Oncol
January 2025
Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania.
Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive lethal malignancy with limited options for treatment and a 5-year survival rate of 11% in the United States. As for other types of tumors, such as colorectal cancer, aberrant lipid synthesis and reprogrammed lipid metabolism have been suggested to be associated with PDAC development and progression.
Aim: To identify the possible involvement of lipid metabolism in PDAC by analyzing in tumoral and non-tumoral tissues the expression level of the most relevant genes involved in the long-chain fatty acid (FA) import into cell.
Atrial arrhythmias with mediastinal lymphadenopathy presentation of isolated atrial myocarditis.
J Arrhythm
February 2025
Department of Electrophysiology, Department of Cardiology AIG Institute of Cardiac Sciences and Research Hyderabad India.
Objectives: We present a case series of patients with granulomatous myocarditis presenting as atrial arrhythmias accompanied by lymphadenopathy.
Background: Atrial myocarditis (AM) may be the cause of atrial fibrillation (AF) in patients without risk factors.
Methods: Patients with atrial fibrillation without risk factors underwent 18F-Fluorodeoxyglucose positron emission tomography (18F-FDG-PET).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!