Background: The aim of this study was to compare two apheresis devices (COBE Trima and COBE Spectra, Gambro BCT).
Study Design And Methods: The study compares 103 Trima procedures with 61 Spectra procedures. The comparison of single-donor PLTs (SDPs) separation parameters and anticoagulant infusion to the donors were the primary targets. Yield and residual amounts of WBCs of SDPs were secondary targets. Residual amounts of WBCs were measured with the Nageotte method.
Results: Trima and Spectra groups were comparable before apheresis. Two procedures were terminated before completion in the Trima group owing to vein damage. Trima infused more anticoagulant--352 +/- 104 mL versus 297 +/- 75 mL (p < 0.01)--and was quicker than Spectra. The time to obtain 3.5 x 10(11) was (median) 55.8 minutes for the Trima machine and 80.3 minutes for Spectra machine (p < 0.001). Regarding leukoreduction, all the SDPs had fewer than 1 x 10(6) WBCs per unit except for one in product obtained by the Trima machine.
Conclusions: The Trima machine is faster and more efficient than the Spectra machine, and both machines allow standard leukoreduced SDPs to be obtained. Although donors receive a higher anticoagulant infusion with the Trima machine, their tolerance is acceptable.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.0041-1132.2003.00598.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[The Causes of Platelet Aggregation in Version 6.4 Trima Accel Automated Blood Collection System and the Comparison of Two Intervention Measures].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2024
Fujian Blood Center, Fuzhou 350004, Fujian Province,China.E-mail:
Article Synopsis
- The study investigates the causes of platelet aggregation in a blood collection system and tests two interventions aimed at reducing this issue.
- In 2021, a group of 72 donors experiencing platelet aggregation were divided into two intervention groups: one increased the anticoagulant ratio, while the other kept donors warm with an electric blanket to enhance blood flow.
- Results showed that the warm treatment led to faster blood flow and decreased collection time and machine alarms, but there was no significant difference in the overall deaggregation of platelets between the two groups.
Plateletpheresis in the Era of Automation: Optimizing Donor Safety and Product Quality Using Modern Apheresis Instruments.
Indian J Hematol Blood Transfus
January 2021
Department of Transfusion Medicine, Apollo Gleneagles Hospitals, Kolkata, 700054 India.
The increases in major surgeries, transplantations and speciality clinics have significantly increased the utilization of platelet concentrates including single donor platelets (SDP). The advantages of SDP or apheresis platelet have been discussed elaborately by previous authors as compared to random donor platelets. Here we share our experiences of plateletpheresis procedures using the modern apheresis machines with regards to product quality and donor safety.
View Article and Find Full Text PDFComparative assessment of single-donor plateletpheresis by Haemonetics MCS plus and Trima Accel.
Asian J Transfus Sci
July 2020
Department of Transfusion Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.
Background: Single-donor platelets (SDPs) prepared by sophisticated automated equipment offer several advantages over random-donor platelets and are being increasingly used to support thrombocytopenic patients. Different apheresis machines working on the principle of centrifugation are being used worldwide to collect platelets. This retrospective study was done to compare plateletpheresis on two automated cell seperators - Haemonetics MCS Plus and Trima Accel.
View Article and Find Full Text PDFBackground: Single donor apheresis platelets are superior in quality, but their usage is limited in a developing country due to cost and time constraints. Hence the product obtained must exceed in terms of yield, donor safety and technical convenience. Previous literature available on cell separators is on older versions.
View Article and Find Full Text PDFApheresis causes complement deposition on red blood cells (RBCs) and RBC antigen alterations, possibly inducing enhanced clearance.
Transfusion
November 2018
Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, University of Amsterdam, Amsterdam, the Netherlands.
Background: Apheresis is increasingly being applied to collect cells or plasma, even allowing the collection of multiple blood components during one procedure. Although the quality of the cellular and plasma products that are obtained by apheresis have been extensively studied and shown to be of high quality, the impact of apheresis on the red blood cells (RBCs) that are returned to the donor has not been investigated.
Study Design And Methods: The effect of the plasma- or plateletpheresis procedures by four different devices-MCS+ (Haemonetics), PCS2 (Haemonetics), Trima Accel (Terumo BCT), and Autopheresis-C (Auto-C, Fresenius Kabi)-on the RBCs that are returned to the donor was tested in a blinded, prospective trial in a cohort of 25 donors.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!