[Effects of Semen Sojae Preparatum on lipid metabolism in ovariectomized rat].

Objective: To investigate the antiatherosclerotic effect of Semen Sojae Preparatum (SSP) and its mechanism.

Methods: 48 rats were randomly divided into sham operation group (sham), ovariectomized group (OVX) and three doses of OVX + SSP groups. SSP was given to OVX + SSP groups 2 weeks after ovariectomy. The levels of serum lipids and lipid peroxidation were detected after 12 weeks treatment.

Results: SSP lowered serum oxidized-low density lipoprotein cholesterol (OX-LDL, P < 0.01), triglyceride (TG, P < 0.01) and malondialdehyde (MDA, P < 0.05 or P < 0.01), and enhanced serum high density lipoprotein cholesterol (HDL-c, P < 0.05 or P < 0.01), polipoprotein A I (apo-AI, P < 0.01) and superoxide dismutase (SOD, P < 0.01) activity.

Conclusion: SSP had effects on regulating lipid and antioxidation. Therefore, it might inhibit atherosclerosis in ovariectomy rats.