AI Article Synopsis
- The tau protein is a key component in the neurofibrillary pathology of various neurodegenerative diseases, particularly affecting the microtubule structure in cells.
- Research using in vitro techniques has been conducted to uncover how tau transitions from a functional part of the cell's structure to an insoluble, harmful polymer.
- The text reviews different modeling techniques for studying tau polymerization, discussing their pros and cons, and highlights findings that enhance our understanding of tau's role in Alzheimer's disease and related conditions.
Article Abstract
The major antigenic component of neurofibrillary pathology in a large number of neurodegenerative diseases consists of the microtubule-associated protein tau. It is currently unclear how tau protein makes the transition from an important component of the microtubule-based cytoskeleton to an insoluble polymerized state. In vitro techniques have been employed to study the polymerization of tau in an effort to understand the underlying molecular mechanisms responsible for this process. These efforts have resulted in the elucidation of roles played by the different parts of the molecule in the polymerization process. Here we discuss the advantages and disadvantages of the various techniques used to model tau polymerization and the discoveries arising from these techniques that have led to a better structural understanding of tau polymerization in relation to Alzheimer's disease and other tauopathies.
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| http://dx.doi.org/10.1021/bi035722s | DOI Listing |
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