AI Article Synopsis
- A 47-year-old male patient has X-linked agammaglobulinemia and severe psoriatic arthritis that began in childhood.
- The case shows that psoriatic arthritis can develop in patients with B-lymphocyte deficiencies, contrary to the belief that it primarily occurs in T-cell disorders.
- The researchers suggest that chronic bowel inflammation may link X-linked agammaglobulinemia to the development of psoriatic arthritis.
Article Abstract
We describe a 47-year-old male patient suffering from X-linked (or Bruton's) agammaglobulinemia with severe psoriatic arthritis (PsA), which started in childhood. PsA has been previously described in T-cell defective disorders, such as HIV infection, but our observation demonstrates that this rheumatic disease can also occur in subjects with B-lymphocyte cell functional impairment. Chronic inflammatory (bacterial?) involvement of the bowel could represent a pathogenetic connection between X-linked agammaglobulinemia and PsA.
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| http://dx.doi.org/10.1080/03009740310003965 | DOI Listing |
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