Mycobacterium aurum was cultured from the Broviac catheter of a 5-year-old child with metastatic Wilms tumor. Removal of the catheter resulted in prompt resolution of the fever and sterilization of the blood culture. This rapidly growing mycobacterium, previously believed to be a commensal, can cause disease in the immunocompromised host.
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The Epiphyte sp. G2112 Produces a Large Diversity of Nobilamide Peptides That Promote Biofilm Formation in Pseudomonads and .
Biomolecules
October 2024
Department of Chemical Ecology/Biological Chemistry, University of Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany.
Article Synopsis
- Isolate sp. G2112 from cucumber plants produces a variety of bioactive compounds including surfactins, iturins, fengycins, and multiple nobilamide peptides, which were characterized using advanced analytical techniques.
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Reduction of hyperglycemia in STZ-induced diabetic mice by prophylactic treatment with heat-killed : possible effects on glucose utilization, mitochondrial uncoupling, and oxidative stress in liver and skeletal muscle.
Front Endocrinol (Lausanne)
October 2024
Department of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand, Al-Koura, Lebanon.
Background: In addition to conventional treatment and modifications in physical activity and diet, alternative strategies have been investigated to manage, prevent, or delay diabetes in humans. In this regard, one strategy has relied on the immunomodulatory properties of mycobacteria, whereby Bacillus Calmette-Guerin, an attenuated live strain of , has been shown to improve glycemic control in patients with diabetes and to alleviate hyperglycemia in selected murine models of diabetes. A novel heat-killed (HK) whole-cell preparation of () is currently under development as a potential food supplement; nevertheless, its potential bioactivity remains largely unknown.
View Article and Find Full Text PDFInvestigation of the antimycobacterial activity of African medicinal plants combined with chemometric analysis to identify potential leads.
Sci Rep
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Biodiscovery Center, Department of Chemistry, University of Pretoria, Hatfield, Private Bag X 20, Pretoria, 0028, South Africa.
The emergence of drug-resistant Mycobacterium tuberculosis strains is a threat to global health necessitating the discovery of novel chemotherapeutic agents. Natural products drug discovery, which previously led to the discovery of rifamycins, is a valuable approach in this endeavor. Against this backdrop, we set out to investigate the in vitro antimycobacterial properties of medicinal plants from Ghana and South Africa, evaluating 36 extracts and their 252 corresponding solid phase extraction (SPE) generated fractions primarily against the non-pathogenic Mycobacterium smegmatis and Mycobacterium aurum species.
View Article and Find Full Text PDFDrug repositioning identifies histone deacetylase inhibitors that promote innate immunity in non-tuberculous mycobacterial infection.
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Medical Research Unit-Zacatecas, Mexican Institute for Social Security-IMSS, Zacatecas, Mexico.
Non-tuberculosis infections in immunocompromised patients represent a cause for concern, given the increased risks of infection, and limited treatments available. Herein, we report that molecules for binding to the catalytic site of histone deacetylase (HDAC) inhibit its activity, thus increasing the innate immune response against environmental mycobacteria. The action of HDAC inhibitors (iHDACs) was explored in a model of type II pneumocytes and macrophages infection by .
View Article and Find Full Text PDFMolecular docking, molecular dynamics simulations and binding free energy studies of interactions between Mycobacterium tuberculosis Pks13, PknG and bioactive constituents of extremophilic bacteria.
Sci Rep
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DST-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, 7505, Cape Town, South Africa.
Mycobacterial pathogens present a significant challenge to disease control efforts globally due to their inherent resistance to multiple antibiotics. The rise of drug-resistant strains of Mycobacterium tuberculosis has prompted an urgent need for innovative therapeutic solutions. One promising way to discover new tuberculosis drugs is by utilizing natural products from the vast biochemical space.
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