Objectives: To compare the biomechanical properties of a prototype intramedullary pin-plate (IMPP) implant specifically designed for equine metacarpophalangeal (MCP) arthrodesis with a dynamic compression plate (DCP) system.
Study Design: In vitro biomechanical testing of paired cadaveric equine forelimbs with a simulated traumatic disruption of the suspensory apparatus, stabilized by one of two methods for MCP arthrodesis.
Animal Population: Twenty-one pairs of adult equine cadaveric forelimbs.
Methods: Each forelimb had the distal sesamoidean ligaments severed to create a disrupted suspensory apparatus. For each forelimb pair, the MCP joint was stabilized with the IMPP in one limb, and a DCP in the other limb. Seven matching limb pairs were tested in axial compression in a single cycle to failure, 7 matching limb pairs were tested in torsion in a single cycle to failure, and 7 matching limb pairs were fatigued tested in axial compression. Mean test variable values for each method were compared using a paired t-test within each group. Significance was set at P<.05.
Results: The mean yield load, yield stiffness, and failure load (axial compression, torsional loading) was significantly greater for the IMPP compared with the DCP system. Mean cycles to failure for axial compression was significantly greater for the IMPP compared with the DCP system. Significance in all tests was P<.0001.
Conclusion: The IMPP was superior to the DCP system in resisting the biomechanical forces most likely to cause failure of MCP joint arthrodesis.
Clinical Relevance: The IMPP implant should be considered for MCP arthrodesis in horses with traumatic disruption of the suspensory apparatus. The specific design of the IMPP implant may facilitate equine MCP arthrodesis and avoid convalescent complications related to cyclic fatigue.
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http://dx.doi.org/10.1046/j.1532-950x.2004.04010.x | DOI Listing |
Front Endocrinol (Lausanne)
January 2025
Department of Family Medicine/Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Background: Amputation confers disabilities upon patients and is linked to cardiometabolic morbidity and mortality. We aimed to compare the incidence of type 2 diabetes (T2DM) between individuals following amputation with those of the general population.
Methods: We performed a population-based retrospective cohort study using the Nationwide Health Insurance Service database.
J Vasc Surg
January 2025
University of Vermont Medical Center, Division of Vascular Surgery and Endovascular Therapy, Burlington, VT. Electronic address:
Objective: To conduct a "Noise Audit" of the Vascular Quality Initiative (VQI) Peripheral Vascular Intervention (PVI) Registry to analyze variation in device selection for similar patients and anatomies.
Methods: We conducted a retrospective cohort study analysis of the VQI PVI Registry. Eight clinical-based, and seven lesion-based scenarios were developed, and the VQI was queried for all procedures matching these descriptions from December 2010 to December 2021.
JAMA Intern Med
January 2025
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Importance: Evidence on cardiovascular benefits and safety of sodium-glucose cotransporter 2 (SGLT-2) inhibitors is mainly from placebo-controlled trials. Therefore, the comparative effectiveness and safety of individual SGLT-2 inhibitors remain unknown.
Objective: To compare the use of canagliflozin or dapagliflozin with empagliflozin for a composite outcome (myocardial infarction [MI] or stroke), heart failure hospitalization, MI, stroke, all-cause death, and safety outcomes, including diabetic ketoacidosis (DKA), lower-limb amputation, bone fracture, severe urinary tract infection (UTI), and genital infection and whether effects differed by dosage or cardiovascular disease (CVD) history.
Sci Rep
January 2025
Department of Biomedical Engineering, University of Houston, 3517 Cullen Blvd, SERC Room 2011, Houston, TX, 77204-5060, USA.
Electro-tactile stimulation (ETS) can be a promising aid in augmenting sensation for those with sensory deficits. Although applications of ETS have been explored, the impact of ETS on the underlying strategies of neuromuscular coordination remains largely unexplored. We investigated how ETS, alone or in the presence of mechano-tactile environment change, modulated the electromyogram (EMG) of individual muscles during force control and how the stimulation modulated the attributes of intermuscular coordination, assessed by muscle synergy analysis, in human upper extremities.
View Article and Find Full Text PDFMedicine (Baltimore)
January 2025
Department of Pain, Department of Hand Surgery, Wuhan Fourth Hospital, Wuhan, Hubei, China.
Digit replantation is often caused by sudden trauma, with 75% of amputated patients being low-income, low-education workers, and adding societal pressure. Orem's self-care model emphasizes self-care and may be an optimal nursing model for digit replantation, but its clinical application and research are limited. This study explores Orem's self-care model's impact on digit replantation.
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