Phenolic thiazoles as novel orally-active neuroprotective agents.

Bioorg Med Chem Lett

Department of Medicinal Chemistry, Ipsen Research Laboratories, Institute Henri Beaufour, 5 Avenue du Canada, 91966 Les Ulis Cedex, France.

Published: January 2004

Novel phenolic thiazoles compounds were prepared which demonstrated potent antioxidant activity and potent in vivo neuroprotection in mitochondrial toxin models and also possess good oral bioavailability.

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http://dx.doi.org/10.1016/j.bmcl.2003.09.077DOI Listing

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