AI Article Synopsis
- Recent advancements in encoding solid supports have sped up the creation and screening of large libraries of chemicals for their bioactivity.
- The review discusses the evolution of these encoding methods and highlights their use in combinatorial synthesis and high-throughput screening of diverse chemical libraries.
- It also touches on the current status of encoded library applications, including innovative techniques in chemical and colloidal encoding.
Article Abstract
The creation of enormous libraries of chemicals and their subsequent screening for bioactivity has been accelerated through recent developments in encoding solid supports. The ability to accurately identify the structure of a biomolecule that has exhibited activity is invaluable and is closer to realisation in the advent of smart nanoscience. In this review the evolution of encoding solid supports as platforms for combinatorial synthesis is traced. Current approaches to encoding solid supports are reviewed and their potential for use as supports for the high-throughput screening of split and mix libraries explored. Finally, a brief consideration of the status of the application of encoded libraries is provided including creative chemical and colloidal encoding.
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| http://dx.doi.org/10.2174/1389201033377256 | DOI Listing |
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