'IBIS' is a set of computer programs concerned with the processing of electron micrographs, with particular emphasis on the requirements for structural analyses of biological macromolecules. The software is written in FORTRAN 77 and runs on Unix workstations. A description of the various functions and the implementation mode is given. Some examples illustrate the user interface.
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Can FreeSurfer Compete with Manual Volumetric Measurements in Alzheimer's Disease?
Curr Alzheimer Res
January 2016
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University Medical Center, P.O. Box 616, 6200 MD Maastricht, The Netherlands.
Alzheimer's disease-related pathology results in tremendous structural and functional changes in the brain. These morphological changes might lead to a less precise performance of automated brain segmentation techniques in AD-patients, which in turn could possibly lead to false allocations of gray matter, white matter or cerebrospinal fluid. FreeSurfer has been shown to operate as an accurate and reliable instrument to measure cortical thickness and volume of neuroanatomical structures.
View Article and Find Full Text PDFGeometric simulation of flexible motion in proteins.
Methods Mol Biol
April 2014
Department of Physics, University of Bath, Bath, UK.
This chapter describes the use of physically simplified analysis and simulation methods-pebble-game rigidity analysis, coarse-grained elastic network modeling, and template-based geometric simulation-to explore flexible motion in protein structures. Substantial amplitudes of flexible motion can be explored rapidly in an all-atom model, retaining realistic covalent bonding, steric exclusion, and a user-defined network of noncovalent polar and hydrophobic interactions, using desktop computing resources. Detailed instructions are given for simulations using FIRST/FRODA software installed on a UNIX/Linux workstation.
View Article and Find Full Text PDFOverall anatomical features and clinical value of the sacral nerve in high resolution computed tomography reconstruction.
Chin Med J (Engl)
November 2010
Department of Medical Imaging, Naval General Hospital, Beijing 100037, China.
Background: Sacral nerve injury is a common complication of pelvic or sacral fractures. As the sacral nerve courser within the sacrum and has a complex relationship with the surrounding tissues, different parts of the sacral plexus injury have similar clinical symptoms and signs. Since lack of specific imaging technique in the diagnosis of sacral nerve injury, especially on multi-segment, multi-site, how to determine the preoperative location and extent of the sacral nerve injury accurately becomes a concern of the general orthopaedic and images practitioners.
View Article and Find Full Text PDF[Study on the overall anatomical features and clinical value of lumbar nerve root, plexus and branches in CT reconstruction].
Zhonghua Wai Ke Za Zhi
June 2009
Department of Orthopaedics and Trauma, Peking University People's Hospital, Beijing 100044, China.
Objective: To identify the overall anatomical characteristics and the clinical value of the lumbar nerves under CT multiplanar reconstruction.
Methods: Fifty normal subjects and 30 patients with LN diseases (51 sides) were selected, including 10 patients with lumber intervertebral disk hernia, eight patients with spinal stenosis, 5 patients with spondylolisthesis, 1 patient with tethered cord syndrome, 1 patient with lumbar scoliosis, and 5 patients with spinal trauma The 16-slice helical CT (Light Speed, GE Company) was used for scanning the lumbar vertebra with multiplanar reconstruction in Workstation (ADW4.1) with UNIX System in DICOM format.
[Features of obturator nerve by high-resolution CT at the same slice with multiplanar planar reconstruction techniques and clinic value thereof].
Zhonghua Yi Xue Za Zhi
December 2007
Image Department, Navy General Hospital, Beijing 100037, China.
Objective: To explore the features of obturator nerve (ON) by high-resolution CT (HRCT) at the same slice with multiplanar planar reconstruction techniques and clinic value thereof.
Methods: The normal lumbar vertebral bodies of 60 healthy adults and the abnormal lumbar vertebral bodies of 31 patients with ON disorders were scanned with 16-slice spiral CT, multiplanar reconstruction was conducted in the Workstation ADW4. 1, with UNIX system and DICOM form.
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