We report that a single relA/spoT-like gene exists on the Rhodobacter capsulatus chromosome, and its mutational loss is lethal. This gene could be mutated only under a mutational background of a null mutation in the nucleoid protein HvrA. This result suggests that there may be a direct link between HvrA-regulated promoters and the ppGpp-related stringent response.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC303453PMC
http://dx.doi.org/10.1128/JB.186.1.235-239.2004DOI Listing

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