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Molecular characterization and bioinformatic analysis of SGU protein in Anopheles culicifacies as target for transmission blocking activity.
Immunol Res
January 2025
Department of Genetics, Maharshi Dayanand University, Rohtak, Haryana, India.
In tropical countries, malaria transmission is the major health issue. To eradicate malaria, health communities depend on the control measure that affects economy and environment of the countries. To overcome these burdens, there is a great need to develop vaccine against malaria, but there is no vaccine to control malaria effectively.
View Article and Find Full Text PDFUnravelling malaria latency: parasite intrinsic and environmental factors influencing dormant liver stages.
Trends Parasitol
January 2025
Department of Molecular Biology, Radboud University, 6525GA, Nijmegen, The Netherlands. Electronic address:
Hypnozoites - dormant Plasmodium parasites in the liver - can cause relapse infections and form a major obstacle to malaria eradication. The mechanisms controlling dormancy remain poorly understood, but hypnozoite formation and reactivation is likely regulated by a combination of parasite intrinsic factors and external stimuli. We reviewed current knowledge of Plasmodium dormancy and drew parallels with dormancy in other parasites and life-cycle stages.
View Article and Find Full Text PDFHuman mobility and malaria risk in peri-urban and rural communities in the Peruvian Amazon.
PLoS Negl Trop Dis
January 2025
Laboratorio ICEMR- Enfermedades Emergentes, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Perú.
Background: While the global burden of malaria cases has decreased over the last two decades, the disease remains a major international threat, even on the rise in many regions. More than 85% of Peruvian malaria cases are in the Amazonian region of Loreto. Internal mobility primarily related to occupation is thought to be primarily responsible for maintaining endemicity and introducing and reintroducing malaria parasites into areas of anophelism, a challenge for malaria eradication.
View Article and Find Full Text PDFRoutine malaria vaccination in Africa: a step toward malaria eradication?
Malar J
January 2025
Department of Information and Communication Technology, Faculty of Computing, University of Delta, Agbor, Delta State, Nigeria.
Malaria remains a significant global health challenge, with nearly half of the world's population at risk of infection. In 2022 alone, malaria claimed approximately 608,000 lives, with 76% of these fatalities occurring in children under the age of five, underscoring the disease's disproportionate impact on vulnerable populations. Africa bears the highest burden, accounting for 94% of global malaria cases.
View Article and Find Full Text PDFPopulation impact of malaria control interventions in the health district of Kati, Mali.
PLoS One
December 2024
Malaria Research and Training Center (MRTC), FMOS-FAPH, Mali-NIAID-ICER, Université des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali.
Background: WHO and its partners have adopted alternative control interventions since the failure to eradicate malaria worldwide in the 1960s and 1970s. The aim of these interventions has been to redesign the control interventions to make them more effective and more efficient. The purpose of this study is to assess the population impact of control interventions implemented at the community health area level.
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