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Mass Spectrometry-Based Protein Footprinting for Protein Structure Characterization.
Acc Chem Res
January 2025
Department of Chemistry, Washington University, St. Louis, Missouri 63130, United States.
ConspectusProtein higher-order structure (HOS) is key to biological function because the mechanisms of protein machinery are encoded in protein three-dimensional structures. Mass spectrometry (MS)-based protein footprinting is advancing protein structure characterization by mapping solvent-accessible regions of proteins and changes in H-bonding, thereby providing higher order structural information. Footprinting provides insights into protein dynamics, conformational changes, and interactions, and when conducted in a differential way, can readily reveal those regions that undergo conformational change in response to perturbations such as ligand binding, mutation, thermal stress, or aggregation.
View Article and Find Full Text PDFAlkaline Hydrogen Evolution Reaction Electrocatalysts for Anion Exchange Membrane Water Electrolyzers: Progress and Perspective.
JACS Au
December 2024
Shanghai Key Laboratory for R&D and Application of Metallic Functional Materials, Institute of New Energy for Vehicles, School of Materials Science and Engineering, Tongji University, 201804, Shanghai, China.
For the aim of achieving the carbon-free energy scenario, green hydrogen (H) with non-CO emission and high energy density is regarded as a potential alternative to traditional fossil fuels. Over the last decades, significant breakthroughs have been realized on the alkaline hydrogen evolution reaction (HER), which is a fundamental advancement and efficient process to generate high-purity H in the laboratory. Based on this, the development of the practical industry-oriented anion exchange membrane water electrolyzer (AEMWE) is on the rise, showing competitiveness with the incumbent megawatt-scale H production technologies.
View Article and Find Full Text PDFChallenges faced by international nursing students undertaking graduate research: Contemporary issues.
Nurse Educ Today
December 2024
School of Nursing and Midwifery, Sub-Faculty of Health Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Frankston, VIC, Australia. Electronic address:
Globalisation has resulted in universities around the world accepting an increasing number of culturally and linguistically diverse students, which facilitates the exchange of knowledge, strengthens cultural awareness and develops a globally adaptive nursing workforce. Graduate research students play an important role in Australian universities' education and research efforts. However, there are limited student perspectives and voices that explore the challenges and barriers faced by international nursing students undertaking graduate research.
View Article and Find Full Text PDFPerceived benefits and challenges one year after receiving brief therapy in a district psychiatric centre. An exploration of patients' and GPs' experiences: A qualitative study.
PLoS One
December 2024
St. Olavs Hospital, Trondheim University Hospital, Nidaros District Psychiatric Centre, Trondheim, Norway.
Background: Scarce treatment resources put pressure on mental health services prompting innovations in service provision. Various innovative strategies have been introduced to provide patients with improved and effective treatment due to increased demands for mental health services. In 2016 a district psychiatric centre (DPC) started a brief treatment program to provide early and effective help for moderate depression and anxiety.
View Article and Find Full Text PDFFraming challenges and polarized issues in invasion science: toward an interdisciplinary agenda.
Bioscience
December 2024
Department of Geography and Environment at Loughborough University, Loughborough, England, United Kingdom.
In a hyperconnected world, framing and managing biological invasions poses complex and contentious challenges, affecting socioeconomic and environmental sectors. This complexity distinguishes the field and fuels polarized debates. In the present article, we synthesize four contentious issues in invasion science that are rarely addressed together: vocabulary usage, the potential benefits of nonnative species, perceptions shifting because of global change, and rewilding practices and biological invasions.
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