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Rationale: Since the onset of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic in 2019, considerable resources have been devoted to developing vaccines to reduce related deaths and the burden of disease. Various vaccine formulations eventually became available and were approved for clinical use. In this article, we have conducted a review of polymyalgia rheumatica (PMR) cases induced by different COVID-19 vaccines [Pfizer: BNT162b2, AstraZeneca: ChAdOx1-S, Moderna: mRNA-1273, and Janssen: Ad26.

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Infections in psoriatic arthritis: association with treatment.

Ther Adv Musculoskelet Dis

October 2024

Joint Rheumatology Program, Clinical Immunology-Rheumatology Unit, Second Department of Medicine and Laboratory, National and Kapodistrian University of Athens School of Medicine, General Hospital of Athens Hippokration, 114 Vass. Sophias Avenue, Athens 115 27, Greece.

Article Synopsis
  • - Serious infections (SIs) are a major concern for patients with psoriatic arthritis (PsA), especially when treated with various medications, including traditional options like methotrexate and newer biologics such as IL-23 inhibitors and JAK inhibitors.
  • - While the overall incidence of SIs in PsA patients is lower than that in rheumatoid arthritis patients, there are ongoing safety concerns, particularly with the potential reactivation of latent infections like tuberculosis when using TNF inhibitors, which can be managed with proper screening.
  • - Newer treatments like IL-23 inhibitors show no increase in common infection risk, but JAK inhibitors are associated with an elevated risk of herpes zoster, highlighting the importance of monitoring and preventive measures in treatment
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Post-transplantation primary central nervous system lymphoma (PT-PCNSL) is a rare neoplasm that occurs in immunocompromised patients. It can manifest months or years after transplantation, presenting with various neurological symptoms. A 64-year-old woman, who had received a liver transplant due to autoimmune hepatitis, presented with generalized weakness, headache, and confusion.

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Article Synopsis
  • The AGA Institute Clinical Practice Update provides guidance on managing gastrointestinal and liver diseases in pregnant patients, incorporating both published evidence and expert opinions.
  • Key recommendations include preconception counseling for reproductive-aged individuals, individualized health interventions during pregnancy, and the coordination of care for high-risk cases involving complex conditions.
  • The guidelines emphasize that while Best Practice Advice statements are based on current literature, they do not have formal ratings for evidence quality, reflecting the need for case-specific assessment.
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