In order to elucidate the role of EBV-LMP1 in the nasopharyngeal carcinogenesis, the expression vector was constructed with subjecting the N-LMP1 gene to double regulation of two specific regulators: EDL-2 and PLUNC-p. The N-LMP1 related transgenic mice model has been constructed successfully by pronucleus microinjection. 58 founder mice were born, 4 of which were founded to be positive by PCR and Southern blot. Immunohistochemistry assay showed that N-LMP1 protein was expressed in the nasopharynx, tongue and forestomach of transgenic mice.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
transgenic mice
12
n-lmp1 transgenic
8
[construction n-lmp1
4
mice
4
mice specific
4
specific regulation
4
regulation region
4
region nasopharynx]
4
nasopharynx] order
4
order elucidate
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!