AI Article Synopsis
- The study found extensive changes in chromosome 9 among 34 patients with esophageal squamous cell carcinoma, using 17 genetic markers to measure loss of heterozygosity (LOH).
- LOH rates varied significantly, ranging from 42.9% to 80%, with three major regions consistently deleted: 9p23-p22, 9q13-q22.3, and 9q34.
- Specific LOH patterns were linked to tumor differentiation, while the research indicated that drinking habits do not significantly influence the risk of esophageal cancer in Chinese individuals.
Article Abstract
Multiple and extensive alterations in chromosome 9 were detected in thirty-four esophageal squamous cell carcinoma patients, using seventeen polymorphic markers localized to chromosome 9 to detect the loss of heterozygosity (LOH) by polymerase chain reaction techniques. The LOH rates detected in this study range from 42.9 to 80.0%. Three commonly deleted regions mapping to 9p23-p22, 9q13-q22.3, and 9q34 were observed. D9S1812 LOH at 9q22.1 was significantly associated with well- and moderately-differentiated tumors; LOH at D9S768, mapping to 9q13-21.3, indicated that drinking habits are not a significant risk factor for Chinese esophagus cancer. Interestingly, no case of microsatellite instability was observed.
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| http://dx.doi.org/10.1016/j.canlet.2003.09.027 | DOI Listing |
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