AI Article Synopsis
- PPARs (alpha, beta/delta, gamma) are transcription factors sensitive to fatty acids and linked to colorectal cancer.
- Researchers analyzed the expression levels of PPAR isoforms and associated proteins in 17 colon cancer patients using real-time PCR.
- The study found that while PPAR isoform expressions varied, the coactivator PGC-1 was significantly decreased in 15 out of 17 tumors, suggesting PPARgamma's activity might be reduced due to both mutation and decreased PGC-1 levels.
Article Abstract
Peroxisome proliferator-activated receptors (PPARs) alpha,beta/delta and gamma are fatty acid sensitive transcription factors that have been implicated in colorectal cancer. To better understand their role, we studied the expression levels of all PPAR-isoforms and transcriptional partners such as the retinoid X receptor alpha (RXRalpha) and PPARgamma-coactivator-1 (PGC-1) by means of real-time PCR in 17 patients with colon cancer. While a heterogeneous pattern was observed for the expression level of the PPAR-isoforms alpha,beta/delta and gamma, the coactivator PGC-1 was significantly decreased in 15 of 17 tumors. Taken together our data suggest that the transcriptional activity of PPARgamma may not only be decreased by mutation but also by downregulation of the coactivator PGC-1 of PPARgamma.
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| http://dx.doi.org/10.1016/j.canlet.2003.08.024 | DOI Listing |
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