Purpose: To determine the role of spherical and irregular aberrations in the optics of the natural eye and after intraocular lens (IOL) implantation in terms of visual acuity, contrast sensitivity, and depth of focus.
Setting: Laboratory of Experimental Ophthalmology, University of Groningen, Groningen, The Netherlands.
Methods: Visual acuity and defocus-specific contrast sensitivity in 11 pseudophakic patients (IOL group) and 27 age-matched phakic subjects were compared. The results were obtained psychophysically. Spherical and irregular aberrations were subsequently estimated by comparing the measured myopic shift (optimum focus of contrast sensitivity at 4 cycles per degree [cpd] compared to that at 16 cpd) and depth of focus with those of theoretical eye models with varying amounts of irregular and spherical aberrations.
Results: The best corrected visual acuity and best corrected contrast sensitivity in the IOL group did not significantly differ from that in the phakic group. The depth of focus was larger in the IOL group at a pupil diameter of 6.0 mm (P<.05). Comparison with theoretical eye models suggested a higher amount of spherical aberration in the IOL group; irregular aberration was almost the same in both groups.
Conclusions: There was a higher amount of spherical aberration in the IOL group, related to a larger depth of focus, without loss of contrast sensitivity at optimum focus or loss of visual acuity. This might contribute to better quality of vision in pseudophakic subjects than in presbyopic phakic subjects.
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http://dx.doi.org/10.1016/j.jcrs.2003.07.007 | DOI Listing |
Zhongguo Fei Ai Za Zhi
November 2024
Yangtze Delta Drug Advanced Research Institute, Nantong 226133, China.
Background: Mutations in the structural domain of the epidermal growth factor receptor (EGFR) kinase represent a critical pathogenetic factor in non-small cell lung cancer (NSCLC). Small-molecule EGFR-tyrosine kinase inhibitors (TKIs) serve as first-line therapeutic agents for the treatment of EGFR-mutated NSCLC. But the resistance mutations of EGFR restrict the clinical application of EGFR-TKIs.
View Article and Find Full Text PDFOphthalmol Glaucoma
January 2025
Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA. Electronic address:
Purpose: To investigate the impact of blood pressure (BP) on rates of retinal nerve fiber layer (RNFL) thinning in glaucomatous eyes with focal ischemic (FI) versus generalized enlargement (GE) optic disc phenotypes.
Design: Prospective cohort study.
Participants: The study included 122 eyes from 101 patients diagnosed with primary open-angle glaucoma.
Clin Radiol
December 2024
Department of Radiology, Affiliated Hospital of Guilin Medical University, No 15, Lequn Road, Guilin, Guangxi, 541001, China. Electronic address:
Aim: To investigate the value of the LR-5, which is based on hepatobiliary phase (HBP) hypointensity, for small hepatocellular carcinoma (sHCC) using LI-RADS v2018 criteria.
Materials And Methods: From January 2015 to December 2021 in institution 1, and from January 2019 to February 2022 in institution 2, 239 patients at high risk for hepatocellular carcinoma (HCC) underwent contrast-enhanced MRI. Two radiologists independently evaluated the imaging features and classified them according to LI-RADS v2018 criteria, calculating the diagnostic performance of LR-5 based on consensus data.
J Optom
January 2025
Department of Ophthalmology, Peking University People's Hospital, Beijing, China; Eye Diseases and Optometry Institute, Beijing, China; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China; College of Optometry, Peking University Health Science Center, Beijing, China.
Purposes: To investigate the 12-month effectiveness of Diverse Segmented Defocus Optics (DSDO) and Defocus Incorporated Multiple Segments (DIMS) spectacle lenses in a real-world clinical population in myopic and pre-myopic Chinese children.
Methods: About 364 subjects prescribed DSDO or DIMS were enrolled. Axial length (AL) and cycloplegic spherical equivalent refraction (SER) changes over 12 months were measured.
J Environ Manage
January 2025
Nanjing Institute of Environmental Sciences (NIES), Ministry of Ecology and Environment (MEE), Nanjing, 210042, China.
Terrestrial ecosystem carbon sinks are a natural deposit that absorbs carbon from the atmosphere. A stable land carbon sink facilitates more reliable predictions of carbon sequestration under changing climate conditions. In contrast, a highly variable land carbon sink will introduce significant uncertainty into model predictions.
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