AI Article Synopsis
- Oral antigens can cause young chicks to develop oral tolerance, but some antigens from pathogens should not lead to this effect.
- Researchers found that when chicks were under 3 days old, exposure to antigens like bovine serum albumin (BSA) consistently resulted in tolerance.
- Maternal antibodies in chicks’ circulatory systems can block this tolerance by preventing the relevant antigens from reaching the central lymphoid organs, thus helping maintain a functional immune response.
Article Abstract
Oral antigens administered to newly hatched chicks induce oral tolerance. Some of the antigens encountered via the gut during this period are pathogen-derived, and should not be tolerogenic. As chicks are protected in early life by maternal antibodies, we assumed that the same antibodies also served to prevent tolerance by blocking the relevant antigen. We used bovine serum albumin (BSA) as a model antigen, and initially showed that tolerance was invariably generated in chicks younger than 3 days of age. We then showed that tolerance and its prevention were due to circulatory BSA: intravenous BSA induced tolerance, BSA was present in serum of previously fed chicks, and tolerance was completely blocked in chicks containing high levels of maternal anti-BSA. These findings indicate that tolerance in the young chick is probably generated in central lymphoid organs, and that maternal antibodies block access of antigen to these organs, thereby preserving immune competence.
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| http://dx.doi.org/10.1016/j.vaccine.2003.07.011 | DOI Listing |
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