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Pain-Related Quality of Life Outcomes in People With Haemophilia A Receiving Emicizumab: A Post Hoc Analysis of the HAVEN 1, 3 and 4 and STASEY Studies.
Haemophilia
December 2024
Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
Introduction: People with haemophilia A (PwHA) experience acute and chronic pain associated with reduced quality of life (QoL).
Aims: This post hoc analysis of pooled data from the HAVEN 1 (NCT02622321), 3 (NCT02847637), 4 (NCT03020160) and STASEY (NCT0319179) studies assessed the impact of emicizumab prophylaxis on pain-related QoL in PwHA.
Methods: PwHA received emicizumab during the four studies.
Effect of Blood on Synovial Joint Tissues: Potential Role of Ferroptosis.
Appl Sci (Basel)
July 2024
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Recurrent bleeding in the synovial joint, such as the knee, can give rise to chronic synovitis and degenerative arthritis, which are major causes of morbidity. Whereas chronic arthropathy affects one-fifth of hemophiliacs, conditions such as rheumatoid arthritis (RA), periarticular and articular fractures, osteochondral autograft transplantation surgery, and anterior cruciate ligament (ACL) injury are also associated with joint bleeding. Synovial joint trauma is associated with inflammation, acute pain, bloody joint effusion, and knee instability.
View Article and Find Full Text PDFEarly Outcome of a Contemporary Unicondylar Knee System.
Cureus
November 2024
Orthopaedics, Anderson Orthopaedic Clinic, Arlington, USA.
Introduction: In 2019, a new fixed-bearing implant for unicondylar knee arthroplasty (UKA) was introduced that incorporated a round-on-flat design featuring an Oxinium femoral component coupled with a highly crosslinked polyethylene bearing surface. Compared to prior implants, the design featured smaller size increments coupled with medial and lateral-specific tibial baseplates. The objective of this study is to describe our institution's early experience with this UKA implant system by evaluating survivorship, reasons for revision, and patient-reported outcome measures (PROMs).
View Article and Find Full Text PDFAssessment of joint health in females with haemophilia: The carriers ultrasound project (CUP) study.
Haemophilia
November 2024
Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Miami-Miller School of Medicine, Miami, Florida, USA.
Introduction: The needs of haemophilia carriers (HC) have been historically overlooked. It is now recognised that HC manifests bleeding symptoms, including haemarthrosis. The natural history of joint health in HC is not yet defined.
View Article and Find Full Text PDFPerioperative Pain Management in Hemophilic Patient Undergoing Orthopedic Surgery: A Narrative Review.
Healthcare (Basel)
October 2024
Orthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy.
Background: Hemophilia type A and B is associated with spontaneous bleeding in muscle tissues and joints. Acute hemarthrosis, representing 70-80% of all bleedings in severe hemophilia patients, is extremely painful. When surgical procedures are needed in hemophiliac patients, perioperative management should be planned with a multidisciplinary team.
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