AI Article Synopsis
- Researchers used in vivo phage display technology in mouse tumor models to identify specific peptide motifs that target different vascular features depending on the type and stage of the tumor.
- This study highlights a new approach to understand the vascular system's diversity during cancer development, creating a preliminary map of its unique characteristics.
- The findings may lead to discovering specific targets for therapies and imaging techniques focused on unique tumor vascular patterns.
Article Abstract
Using in vivo phage display technology with murine tumorigenesis models, two reports have identified peptide motifs that selectively home to distinct molecular vascular targets in a tumor type- and stage-specific manner (Hoffman et al., 2003 and Joyce et al., 2003 [this issue of Cancer Cell]). By probing the surface-protein repertoire of these unique vascular beds, a pioneering draft of a molecular roadmap to decipher the heterogeneity of the vascular system in the context of carcinogenic progression has been plotted. Analysis of these phage peptides that differentially home to dysplastic or invasive tumor vasculature will lay the foundation for identifying unique functional tumor vascular-specific motifs that could potentially be applied to targeted therapeutic and imaging modalities.
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| http://dx.doi.org/10.1016/s1535-6108(03)00278-2 | DOI Listing |
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