AI Article Synopsis
- Male contraception methods like coitus interruptus, condoms, and vasectomy have remained largely unchanged since the 19th century, highlighting the urgent need for new options.
- Current research is focusing on hormonal approaches that suppress sperm production, with androgen-progestin combinations showing the most promise for effective male contraception.
- To expand available contraceptive options and ensure their long-term safety, further development of new hormonal steroids is essential.
Article Abstract
Methods that are available for male contraception, namely coitus interruptus, condoms, and vasectomy, have been used since the 19th century. With the exceptions of a few improvements of these methods, no major progress has been made with respect to introducing new male contraceptives since then. It is extremely urgent to develop new, safe, effective, and reversible male contraceptive methods. Among all male contraceptive methods that are being investigated, the hormonal approach is the closest to clinical application. Hormonal contraception provides pregnancy protection by means of spermatogenic suppression. Androgen-progestin regimens currently represent the best available hormonal combination for induction of a profound suppression of spermatogenesis. Further development of new steroids is mandatory for increasing the choices of available contraceptive formulations and to optimize long-term safety of these regimens.
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| http://dx.doi.org/10.1590/s0041-87812003000500007 | DOI Listing |
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