Background: Electroconvulsive therapy (ECT) stimulus parameters, such as pulse amplitude, pulse width, pulse frequency, and stimulus duration, differently influence seizure threshold and, possibly, other neurobiological effects of ECT. We examined the influence of these parameters on the EEG power spectrum in an animal model.
Methods: Adult, male, Wistar rats (n=54) were randomized to receive one of five differently constituted (approximately) 30-mC electroconvulsive shock (ECS) stimuli administered once on alternate days for a total of three ECS. A single-lead, unipolar EEG recording was obtained before, during, and immediately after each ECS seizure. EEG power was computed in eight frequency bands from 2 to 40 Hz. Greater ictal EEG power, greater postictal EEG suppression, and greater interictal EEG power, especially in lower frequency bands, were a priori defined as proxies of seizure efficacy.
Results: Motor and EEG seizure duration and a proxy for seizure generalization did not differ significantly across the five stimulus groups. Despite equivalent charge, the five stimuli varied widely in their effects on the EEG proxies of seizure efficacy. The narrow (0.6 milliseconds) pulse width, high (100 Hz) pulse frequency combination was best associated with EEG proxies of seizure efficacy; with this combination, a longer stimulus train duration appeared superior to a greater pulse amplitude. The wide (2 milliseconds) pulse and low (30 Hz) frequency combination was least associated with EEG proxies of efficacy. Stimulus "on" time, number of pulses delivered, and the rate of delivery of charge were not associated with the EEG proxies; the former finding questions the validity of dosing ECT in units of charge.
Conclusions: These findings suggest a rationale for optimizing stimulus parameter choices during ECT and provide a framework for the evaluation of electrical aspects of the ECT stimulus.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00124509-200312000-00005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neural Sensitivity to Ambiguous Social Exclusion Reflects Information Processing Bias in Midadolescents With Higher Levels of Aggression.
Dev Psychobiol
January 2025
Department of Psychology, University of Texas at Dallas, Richardson, Texas, USA.
Aggression is commonly associated with increased experiences of peer rejection and maladaptive social information processing biases throughout development. Little is known about the neural correlates of peer rejection that might underlie social information processing biases, and whether these neural correlates are common or different across early- and mid-adolescents on a continuum of aggression. Using the Cyberball task, we examined mediofrontal theta (4-7 Hz) event-related EEG spectral power during conditions of explicit and ambiguous social exclusion in 117 participants (57 early adolescents, ages 10-12 years, and 60 mid-adolescents, ages 14-16 years).
View Article and Find Full Text PDFTheta transcranial alternating current stimulation over the prefrontal cortex enhances theta power and working memory performance.
Front Psychiatry
January 2025
Centre for Psychiatry and Psychotherapy, Justus-Liebig University Giessen, Giessen, Germany.
Introduction: Transcranial alternating current stimulation (tACS) is a promising tool for modulating brain oscillations. This study investigated whether 5 Hz tACS could modulate neural oscillations in the prefrontal cortex and how this modulation impacts performance in working memory (WM) tasks.
Method: In two sessions, 28 healthy participants received 5 Hz tACS or sham stimulation over the left dorsolateral prefrontal cortex (DLPFC) while performing tasks with high and low WM loads.
Beta oscillations predict the envelope sharpness in a rhythmic beat sequence.
Sci Rep
January 2025
RITMO Centre for Interdisciplinary Studies in Rhythm, Time and Motion, University of Oslo, Forskningsveien 3A, Oslo, 0373, Norway.
Periodic sensory inputs entrain oscillatory brain activity, reflecting a neural mechanism that might be fundamental to temporal prediction and perception. Most environmental rhythms and patterns in human behavior, such as walking, dancing, and speech do not, however, display strict isochrony but are instead quasi-periodic. Research has shown that neural tracking of speech is driven by modulations of the amplitude envelope, especially via sharp acoustic edges, which serve as prominent temporal landmarks.
View Article and Find Full Text PDFEarly-phase EEG power spectrum analysis may differentiate acute encephalopathy with biphasic seizures and late reduced diffusion from prolonged febrile seizures.
Epilepsy Res
January 2025
Department of Pediatric Neurology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan. Electronic address:
Background: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is clinically characterized by biphasic seizures associated with mild to severe neurological sequelae and is the most common subtype of acute encephalopathy in Japan, accounting for around 30 % of cases. The present study retrospectively analyzed the utility of electroencephalography (EEG) in determining the optimal method of diagnosing AESD at the early stage.
Methods: This study explores early power value differences to differentiate acute encephalopathy from prolonged febrile seizure (FS).
Electroencephalographic markers in Major Depressive Disorder: insights from absolute, relative power, and asymmetry analyses.
Front Psychiatry
January 2025
Feneryolu Medical Center, Üsküdar University, Istanbul, Türkiye.
Introduction: Major Depressive Disorder (MDD) leads to dysfunction and impairment in neurological structures and cognitive functions. Despite extensive research, the pathophysiological mechanisms and effects of MDD on the brain remain unclear. This study aims to assess the impact of MDD on brain activity using EEG power spectral analysis and asymmetry metrics.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!