Background: Patients with idiopathic hypercalciuria are predisposed to osteoporosis despite their high enteral calcium absorption. Conversely, low calcium absorption has been reported in patients with osteoporosis. Because bone loss occurs earlier in women, this work explores the relationship between bone mineral density (BMD) and calcium absorption in premenopausal and postmenopausal hypercalciuric stone-forming women.
Methods: BMD and intestinal calcium absorption were compared in 64 hypercalciuric and 42 normocalciuric calcium stone-forming women. Calcium absorption was assessed by using strontium as a surrogate marker for calcium. Strontium was administered to patients as an oral load, then measured in blood to calculate absorption after 60 minutes. Femoral and lumbar-spine BMD were measured by dual-energy x-ray absorptiometry.
Results: Strontium absorption was significantly increased in hypercalciuric stone formers, whereas BMD z score was decreased in hypercalciuric patients at the lumbar spine, but not the femur. The increase in strontium absorption was detected in both postmenopausal (n = 29) and premenopausal (n = 35) hypercalciuric patients. The decrease in lumbar-spine BMD was confirmed in postmenopausal, but not premenopausal, hypercalciuric patients. Strontium absorption was greater in hypercalciuric patients with a lumbar-spine BMD z score of -2 or less (n = 10) than in those with a score greater than -2 (n = 54). Multiple stepwise regression showed that lumbar-spine BMD was related negatively to intestinal strontium absorption and age in hypercalciuric patients.
Conclusion: Results of the strontium absorption test suggest that the increase in calcium absorption is associated with a decrease in lumbar-spine BMD in hypercalciuric stone-forming women. Hypercalciuric stone-forming women with high calcium intestinal absorption denote a group of patients predisposed to loss of bone mass.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1053/j.ajkd.2003.08.018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prebiotics as modulators of colonic calcium and magnesium uptake.
Acta Physiol (Oxf)
February 2025
Institute for Molecular Medicine, Health and Medical University Potsdam, Potsdam, Germany.
Ca and Mg are essential nutrients, and deficiency can cause serious health problems. Thus, lack of Ca and Mg can lead to osteoporosis, with incidence rising both in absolute and age-specific terms, while Mg deficiency is associated with type II diabetes. Prevention via vitamin D or estrogen is controversial, and the bioavailability of Ca and Mg from supplements is significantly lower than that from milk products.
View Article and Find Full Text PDFIntegrated role of biochar and PGPR (Leclercia adecarboxylata HW04) in enhancing cadmium phytoremediation and stress tolerance in Glycine max L.
Plant Physiol Biochem
January 2025
Department of Applied Biosciences, Kyungpook National University, 41566, Daegu, Republic of Korea. Electronic address:
Plant growth-promoting rhizobacteria (PGPR) and biochar (BC) are recognized as effective biological agents for enhancing stress tolerance and mitigating heavy metal toxicity in crops. Therefore, this study aims to investigate the effects of the cadmium (Cd)-resistant PGPR strain Leclercia adecarboxylata HW04 (>4 mM Cd resistance) on soybean plants exposed to 300 μM Cd. HW04 was observed to possess the innate ability to synthesize indole-3-acetic acid and exopolysaccharides, which facilitated the absorption of Cd in the medium.
View Article and Find Full Text PDFAdding colour to ion-selective membranes.
Talanta
January 2025
Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland. Electronic address:
An idea of using ion-exchanger salt containing optically active cations to prepare ion-selective membranes is proposed. Although the presence of an ion-exchanger in the composition of neutral ionophore based sensors is necessary, the choice of available salts for cation-selective sensors preparation, is usually limited to sodium or potassium compounds. In this work we propose application of an alternative salt, using a cation optically active both in absorption and emission mode as a mobile one.
View Article and Find Full Text PDFEnhancing Radiation Shielding Capabilities with Epoxy-Resin Composites Reinforced with Coral-Derived Calcium Carbonate Fillers.
Polymers (Basel)
January 2025
Faculty of Radiological Technology, Rangsit University, Pathumthani 12000, Thailand.
This study investigates the development of epoxy-resin composites reinforced with coral-derived calcium carbonate (CaCO) fillers for enhanced radiation shielding and mechanical properties. Leveraging the high calcium content and density of coral, composites were prepared with filler weight fractions of 0%, 25%, and 50%. SEM and EDS analyses revealed that higher filler concentrations (50%) increased particle agglomeration, affecting matrix uniformity.
View Article and Find Full Text PDFInvestigating the salinity distribution using field measurements in the semi-arid region of southern Ethiopia.
Environ Monit Assess
January 2025
Natural Resources Management, Irrigation, and Salinity Program, Arba Minch Agricultural Research Center, PO.BOX, 2228, Arba Minch, Ethiopia.
This study investigated the distribution of salinity and sodicity in the irrigated areas of Abaya Chamo. Representative water and soil samples were collected from different soil depths (0-30 cm and 30-60 cm). Sodium absorption ratio (SAR), electrical conductivity (Ec), pH, exchange sodium, magnesium, calcium, and potassium cations, and exchange sodium percentage (ESP) of the sampled sites were analyzed for soil salinity classification and severity analysis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!