AI Article Synopsis
- The study aimed to assess a surgical protocol for implanting fetal tissue into the brains of patients with Huntington's disease.
- Four patients received suspensions of human fetal striatal tissue in specific brain areas, and post-surgery MRI confirmed the correct placement of the grafts.
- The findings showed variability in how well the grafts survived, but overall, the protocol was deemed safe, effective, and consistent with other research.
Article Abstract
The purpose of this study was to evaluate our surgical protocol for the preparation and delivery of suspensions of fetal tissue into the diseased human brain. We implanted suspensions of human fetal striatal anlage into the right caudate and putamen of four patients with Huntington's disease. Postoperative 3 tesla MR imaging confirmed accurate graft placement. Variability in graft survival was noted and the MR signal changes over 6 months revealed persistent hyperintense signal on T2-weighted images. Our results are consistent with those described by other groups and indicate that our surgical protocol is safe, accurate, and reproducible.
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| http://dx.doi.org/10.3727/000000003108747316 | DOI Listing |
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