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Veratridine Induces Vasorelaxation in Mouse Cecocolic Mesenteric Arteries.
Toxins (Basel)
December 2024
Univ. Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.
The vegetal alkaloid toxin veratridine (VTD) is a selective voltage-gated Na (Na) channel activator, widely used as a pharmacological tool in vascular physiology. We have previously shown that Na channels, expressed in arteries, contribute to vascular tone in mouse mesenteric arteries (MAs). Here, we aimed to better characterize the mechanisms of action of VTD using mouse cecocolic arteries (CAs), a model of resistance artery.
View Article and Find Full Text PDFInhibitory Postsynaptic Potentials Participate in Intracellular and Extracellular Theta Rhythms in the Hippocampus: A Personal Narrative.
Hippocampus
January 2025
Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.
The hypothesis that the hippocampal theta rhythm consists of inhibitory postsynaptic potentials (IPSPs) was critical for understanding the theta rhythm. The dominant views in the early 1980s were that intracellularly recorded theta consisted of excitatory postsynaptic potentials (EPSPs) with little participation by IPSPs, and that IPSPs generated a closed monopolar field in the hippocampus. I (Leung) conceived of a new model for generation of the hippocampal theta rhythm, with theta-rhythmic IPSPs as an essential component, and thus sought to reinvestigate the relation between theta and IPSPs quantitatively with intracellular and extracellular recordings.
View Article and Find Full Text PDFThe vascular effects of peppermint ( L) on aorta in a mouse model: an and computational study.
J Biomol Struct Dyn
December 2024
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
The present study examined the vascular effects of peppermint or mint () using an abdominal aortic rings model. Concentration-response curves for mint oil were generated after precontracting isolated mouse aorta with phenylephrine. The effect of different receptor antagonists and ion channel or enzyme inhibitors on the vasorelaxant potential of mint oil were studied.
View Article and Find Full Text PDFNetwork Pharmacology and Molecular Dynamics Simulations Reveal the Mechanism of Total Alkaloid Components in Anisodus Tanguticus (Maxim.) Pascher in Treating Inflammation and Pain.
Chem Biodivers
September 2024
CAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining, 810008, China.
Article Synopsis
- This study investigated how total alkaloids from Anisodus tanguticus (AT) provide anti-inflammatory and pain relief effects using a specific cell model and advanced analytical techniques.
- Researchers identified the main components of AT, including anisodamine and scopolamine, and examined their interactions and potential therapeutic targets using various biomedical databases and tools.
- The findings suggest that certain compounds, particularly fabiatrin and scopolin, could serve as effective anti-inflammatory and analgesic agents through specific biological pathways.
Evidence of an excitatory purinergic innervation in mouse corpus cavernosum smooth muscle.
J Sex Med
October 2024
Smooth Muscle Research Centre, Dundalk Institute of Technology, Dundalk, County Louth A91 K584, Ireland.
Background: Evidence suggests that the corpus cavernosum smooth muscle (CCSM) cells of several species, including humans, express purinergic P2X receptors, but it is not known if the corpus cavernosum has an excitatory purinergic innervation.
Aim: In this study we aimed to determine if the mouse CCSM has a functional purinergic innervation.
Methods: Mouse CCSM myocytes were enzymatically isolated and studied using the perforated patch configuration of the patch clamp technique.
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