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Fatal acute liver failure due to reactivation of hepatitis B following treatment with fludarabine/cyclophosphamide/rituximab for low grade non-Hodgkin's lymphoma.
Eur J Med Res
October 2008
Department of Internal Medicine I, University Hospital of Bonn, Germany.
Background: Reactivation of chronic hepatitis B in HBsAg carriers is a well known complication of chemo?therapy. The clinical spectrum ranges from asymptomatic hepatitis to fatal hepatic failure. Although it impairs the prognosis of cancer treatment, it may be overlooked due to other possible causes of liver damage.
View Article and Find Full Text PDF[Off label use in long-term anticoagulation after liver transplantation due to phenprocoumon-induced hepatic failure].
Med Monatsschr Pharm
July 2006
Universitätsklinikum Heidelberg, Medizinische Klinik (Krehl-Klinik), Abteilung Innere Medizin VI, Klinische Pharmakologie und Pharmakoepidemiologie, Im Neuenheimer Feld 410, 69120 Heidelberg.
Background: Drug therapy should be individualised according to criteria of efficacy, adverse effects, and treatment adherence. This is particularly important at the interface of inpatient and ambulatory care. Aspects of drug approval (labelling) and individual refunding by health care insurances should also be taken into account.
View Article and Find Full Text PDF[Off-label use in long-term anticoagulation after liver transplantation due to phenprocoumon-induced hepatic failure].
Med Klin (Munich)
December 2005
Abteilung Innere Medizin VI, Klinische Pharmakologie und Pharmakoepidemiologie, Medizinische Klinik (Krehl-Klinik), Universitätsklinikum Heidelberg, Heidelberg.
Background: Drug therapy should be individualized according to criteria of efficacy, adverse effects, and treatment adherence. This is particularly important at the interface of inpatient and ambulatory care. Aspects of drug approval (labeling) and individual refunding by health care insurance should also be taken into account.
View Article and Find Full Text PDFPhenprocoumon-induced liver disease ranges from mild acute hepatitis to (sub-) acute liver failure.
J Hepatol
July 2004
First Department of Internal Medicine, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany.
Background/aims: Except for bleeding complications, other serious adverse reactions of coumarin anticoagulants such as hepatotoxicity or skin necrosis are comparatively rare. Nonetheless, a small number of coumarin-induced (sub-) acute liver failures has been published.
Methods: A retrospective analysis was performed of patients treated for liver disease between 1992 and 2002 at our department to evaluate the incidence, clinical findings and histopathology of coumarin-induced hepatotoxicity.
Phenprocoumon-induced hepatitis as an immunologically mediated drug allergic complication of antithrombotic therapy.
Thromb Haemost
December 2003
Institute of Clinical Chemistry, Laboratory for Haematology and Immunology, Faculty of Clinical Medicine Mannheim, University Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68135 Mannheim, Germany.
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