AI Article Synopsis
- Researchers utilized computer-based screening and experimental analysis to identify a new gene called TEPP, which is expressed specifically in the testis, prostate, and placenta, but not in other essential human tissues.
- TEPP has a major transcript size of 1.0kb and encodes a protein with a molecular weight of 30.7kDa, suggesting it may be secreted due to the presence of a signal peptide.
- The discovery of a splice variant of TEPP, along with its conservation across different species, implies its potential importance in reproductive biology.
Article Abstract
We have combined computer-based screening and experimental expression analysis to identify genes that are expressed in normal prostate and/or prostate cancer but not in essential human tissues. Using this approach we identified a new gene that is specifically expressed in testis, prostate, and placenta. The gene has one major transcript of 1.0kb in size and encodes for a protein of 30.7kDa molecular weight. We named this gene TEPP (expressed in testis, prostate, and placenta). The amino acid sequence analysis of TEPP using SignalP program shows that it has a signal peptide with a predicted cleavage site between amino acids 19 and 20, indicating that it might be a secreted protein. Analysis of the predicted TEPP orthologs from different species shows that these proteins are highly conserved in chordates. In addition we have identified a splice variant of TEPP, which encodes a 37kDa protein. In conclusion, a combination of bioinformatic and molecular approaches is useful in the identification of genes expressed in specific tissues. Selective expression of TEPP in testis, prostate, and in placenta and its high conservation among different species indicate that TEPP might have a role in reproductive biology.
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| http://dx.doi.org/10.1016/j.bbrc.2003.11.031 | DOI Listing |
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