AI Article Synopsis
- NGF helps regulate an enzyme called ChAT, which is affected by Alzheimer's disease.
- The study compared two methods of delivering beta-NGF in aged rats with cognitive deficits to see how they impact ChAT levels and behavior.
- Results showed that administering beta-NGF directly into the brain (icv) increased ChAT expression in specific areas and improved behavioral recovery, highlighting the importance of the delivery method for effective treatment.
Article Abstract
The nerve growth factor (NGF) is known to participate in the regulation of the expression levels and activity of the choline acetyltransferase (ChAT) in the nervous system. This enzyme is sensitive to the degenerative changes found in Alzheimer's disease (AD). We compared the effectiveness of intraparenchymal (ip) and intracerebroventricular (icv) administration of the murine beta-NGF (beta-NGFm) produced in our laboratories, through the determination of the expression levels and activity of the ChAT, and the evaluation of behavioral recovery in aged rat with cognitive deficit. Our results indicated that icv infusion of beta-NGFm stimulates the expression levels of ChAT gene in the striatum of old rats. Remarkable losses in the ChAT activity were observed in the septum and striatum of old rats. Exogenous administration of beta-NGFm produced a significant increase of ChAT activity in these brain regions differentially according to the administration pathway. The behavioral studies demonstrated that the administration pathway is an important factor in order to obtain the best results for a neurorestorative treatment.
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| http://dx.doi.org/10.1016/j.bbrc.2003.10.198 | DOI Listing |
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