AI Article Synopsis
- * The study focuses on the effects of AICD in the G1 phase of the cell cycle, where T cells are more vulnerable to death, and examines the role of survivin, a protein that inhibits cell death.
- * Results show that survivin is minimally expressed during G1 phase but is more prevalent in G2/M phase, and its temporary over-expression in G1 can reduce AICD induction, indicating survivin's protective role against cell death in this phase.
Article Abstract
A process termed activation-induced cell death (AICD) is responsible for peripheral T cell tolerance after negative selection of self-reactive T cells, and deletion of hyperactivated T cells following the immune response. Cells in G1 phase of the cell cycle are most susceptible to AICD. We have investigated the relationship between the induction of AICD by phorbol 12-myristate 13-acetate plus ionomycin during the cell cycle and the expression of survivin, an inhibitor of the apoptosis protein (LAP) family. AICD was highly induced in cells of the human T cell line Jurkat E6.1 arrested in G1 phase, whereas survivin was hardly expressed in G1 and instead it was highly expressed in G2/M. Moreover, transient over-expression of survivin in G1 partially blocked the induction of AICD. These results suggest that survivin inhibits the induction of AICD, especially in G1 phase.
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