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Biomechanical Principles of Spinal Deformity Correction in the Thoracolumbar Spine.
J Am Acad Orthop Surg
January 2025
From the Children's Mercy Hospital, Kansas City, MO (Shaw), Children's Health Ireland at Temple Street, Dublin, Ireland (O'Sullivan), the Department of Mechanical Engineering, Polytechnique Montreal, Montreal, Quebec, Canada (Wang and Aubin), and the Sainte-Justine University Hospital Center, Montreal, Quebec, Canada (Wang and Aubin).
Thoracolumbar spinal deformities are a pervasive condition affecting the adolescent and adult patient population. These deformities represent three-dimensional alterations in the coronal, sagittal, and transverse planes with implication on the local, regional, and global alignment. With continued studies, the importance of the overall correction on long-term outcomes has been established.
View Article and Find Full Text PDFThe landscape of family medicine in India - A cross-sectional survey study.
PLOS Glob Public Health
January 2025
Department of Family and Community Medicine, University of Toronto, Toronto, Canada.
Family medicine was recognized as a distinct specialty in India in the early 1980s, but it is at an early stage of implementation. There are few training programs, and little is known about family physicians' training, perceptions, and current practices. This paper describes the findings from the first national survey of family medicine in India.
View Article and Find Full Text PDFS100A8 regulates postoperative responses following tooth extraction in rats.
Odontology
January 2025
School of Stomatology, Shandong Second Medical University, Weifang, 261053, Shandong, China.
The reduction in alveolar ridge height and width after tooth extraction poses a substantial challenge for dental implant restoration. This study aimed to observe the roles of S100A8 in the inflammatory response and bone resorption following tooth extraction. Rat mandibular second molars were extracted.
View Article and Find Full Text PDFInnate Immunity Never "NODs" Off: NLRs Regulate the Host Anti-Viral Immune Response.
Immunol Rev
March 2025
Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech, Roanoke, Virginia, USA.
A robust innate immune response is essential in combating viral pathogens. However, it is equally critical to quell overzealous immune signaling to limit collateral damage and enable inflammation resolution. Pattern recognition receptors are critical regulators of these processes.
View Article and Find Full Text PDFMicrobial surveillance versus cytokine responsiveness in native and non-native house sparrows.
Biol Lett
January 2025
Global Enviornmental and Genomic Health Sciences, University of South Florida, Tampa, FL 33612, USA.
The success of introduced species often relies on flexible traits, including immune system traits. While theories predict non-natives will have weak defences due to decreased parasite pressure, effective parasite surveillance remains crucial, as infection risk is rarely zero and the evolutionary novelty of infection is elevated in non-native areas. This study examines the relationship between parasite surveillance and cytokine responsiveness in native and non-native house sparrows, hypothesizing that non-natives maintain high pathogen surveillance while avoiding costly inflammation.
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