Rheumatoid arthritis can cause joint erosion and deformity, pain, stiffness, and decreased function and range of motion. Early diagnosis is crucial to prevent permanent joint damage. In this article, Drs Williams and Fye discuss articular and extra-articular manifestations of rheumatoid arthritis as well as the evolving treatment approaches to this complex disease.
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Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D.
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Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Protein citrullination modification plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA), and anti-citrullinated protein antibodies (ACPAs) are extensively employed for clinical diagnosis of RA. However, there remains limited understanding regarding specific citrullinated proteins and their implications in the progression of RA. In this study, we screen and verify insulin-like growth factor-2 mRNA binding protein 1 (IGF2BP1) as a novel citrullinated protein with significantly elevated citrullinated level in RA.
View Article and Find Full Text PDFRefining insights into rheumatoid arthritis-associated liver dysfunction: Opportunities for methodological advancements and clinical implications.
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Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. Electronic address:
Pruritic eruption associated with rheumatoid arthritis: rheumatoid neutrophilic dermatitis.
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Department of Dermatology, Mayo Clinic in Florida, Jacksonville, Florida, USA
Association between acetabular coverage over femoral head and rate of joint space narrowing in non-arthritic hips.
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Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
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