AI Article Synopsis
- The study examines the impact of the synthetic peptide Epitalon on various genetic factors in the lymphocytes of individuals aged 76-80.
- Epitalon was found to activate ribosomal genes and promote the decondensation of specific types of heterochromatin, potentially reversing some age-related genetic repression.
- The findings suggest that Epitalon can enhance chromatin activity in older cells, indicating its potential as a therapeutic agent for age-related genetic changes.
Article Abstract
Unlabelled: OBJECTIVES and design. We have studied the effect of synthetic peptide Epitalon on the activity of ribosomal genes, denaturation parameters of total heterochromatin, polymorphism of structural C-heterochromatin and the variability of facultative heterochromatin in cultured lymphocytes of persons aged 76-80 years.
Results: The obtained data demonstrate that Epitalon induces the activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin and the release of genes repressed due to the age-related condensation of euchromatic chromosome regions.
Conclusions: Epitalon has shown its ability to activate chromatin by modifying heterochromatin and heterochromatinized chromosome regions in the cells of older persons.
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