AI Article Synopsis
- Bacteria in natural habitats often experience periods of growth arrest, but little is known about how this affects their mutation rates and evolution.
- A study on Escherichia coli in prolonged stationary phase found about 0.03 slightly deleterious mutations per genome per day, which is significantly higher than expectations based on fast-growing cells.
- These results could change how we understand bacterial evolution and the development of pathogenic traits in bacteria.
Article Abstract
In natural habitats, bacteria spend most of their time in some form of growth arrest. Little is known about deleterious mutations in such stages, and consequently there is limited understanding of what evolutionary events occur. In a deleterious mutation accumulation experiment in prolonged stationary phase of Escherichia coli, about 0.03 slightly deleterious mutations were observed per genome per day. This is over an order of magnitude higher than extrapolations from fast-growing cells, but in line with inferences from observations in adaptive stationary phase mutation experiments. These findings may affect understanding of bacterial evolution and the emergence of bacterial pathogenicity.
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| http://dx.doi.org/10.1126/science.1087911 | DOI Listing |
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