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Specialized pericyte subtypes in the pulmonary capillaries.
EMBO J
January 2025
Division of Pulmonary Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Pericytes are essential for capillary stability and homeostasis, with impaired pericyte function linked to diseases like pulmonary arterial hypertension. Investigating pericyte biology has been challenging due to the lack of specific markers, making it difficult to distinguish pericytes from other stromal cells. Using bioinformatic analysis and RNAscope, we identified Higd1b as a unique gene marker for pericytes and subsequently generated a knock-in mouse line, Higd1b-CreERT2, that accurately labels pericytes in the lung and heart.
View Article and Find Full Text PDFBackground: Though European Respiratory Society and American Thoracic Society (ERS/ATS) guidelines for pulmonary function test (PFT) interpretation recommend the use of the forced vital capacity (FVC) lower limit of normal (LLN) to exclude restriction, recent data suggest that the negative predictive value (NPV) of the FVC LLN is lower than has been accepted, particularly among non-Hispanic Black patients. Using a machine learning (ML) model-rather than the FVC LLN-to exclude restriction may improve the accuracy and equity of PFT interpretation. We sought to develop and externally validate a ML model to predict restriction from spirometry and to assess the potential impact of this model on PFT interpretation.
View Article and Find Full Text PDFEvaluation and Improving the Quality of Arterial Blood Gas Interpretation Among Junior Doctors in Aswan University Hospital: A Clinical Audit.
Cureus
December 2024
Pulmonary Medicine, Aswan University Hospitals, Aswan, EGY.
Article Synopsis
- Arterial blood gas (ABG) analysis is crucial for diagnosing critical conditions in patients, and misinterpretation can lead to serious management issues.
- A study conducted at Aswan University Hospitals involved 273 healthcare professionals and assessed their ABG interpretation skills before and after targeted educational interventions over two weeks.
- Results indicated significant improvements, with accuracy in interpreting ABG results increasing from 71.8% to 90.2% and enhanced skills in identifying acid-base disturbances and distinguishing between respiratory and metabolic issues.
Lung Function Parameters among Adult Bangladeshi Population.
Mymensingh Med J
January 2025
Dr Rajashish Chakrabortty, Associate Professor, Department of Respiratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh; Email:
The standard values of lung function parameters obtained from Western populations do not agree with that of the people of Bangladesh. The study aimed to establish valid and up-to-date spirometry predictive values for the general population in Bangladesh. This cross-sectional observational study was conducted over six months from February 2020 to July 2020 in the Department of Respiratory medicine of Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh.
View Article and Find Full Text PDFCXCL12 restricts tumor growth by suppressing the Ras, ERK1/2, c-Myc, and the immune checkpoint PD-L1 pathways.
Proc Natl Acad Sci U S A
December 2024
The Rappaport Faculty of Medicine and Research Institute, and the Rappaport Technion Integrated Cancer Center (R-TICC), Technion-Israel Institute of Technology, Haifa 3109601, Israel.
Cytokines constitute a family of proteins that modulate the immune system and are secreted by many cells. CXCL12, along with its receptor CXCR4, are essential players in numerous processes. Dysregulation of their function underlie the mechanism(s) of several pathologies, including malignancies.
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